Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …

Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Disease susceptibility and resistance are important factors for the conservation of
endangered species, including elephants. We analyzed pathology data from 26 zoos and …

The risk of developing cancer is correlated with body size and lifespan within species.
Between species, however, there is no correlation between cancer and either body size or …

Cetaceans are the longest-living species of mammals and the largest in the history of the
planet. They have developed mechanisms against diseases such cancer, although the …

Most solid tumors are aneuploid, and p53 has been implicated as the guardian of the
euploid genome. Previous experiments using human cell lines showed that aneuploidy …

Contemporary studies on aging and longevity have largely overlooked the role that
adaptation plays in lifespan variation across species. Emerging evidence indicates that the …

Plant stem cells have several extraordinary features: they are generated de novo during
development and regeneration, maintain their pluripotency, and produce another stem cell …

Extreme longevity has evolved multiple times during the evolution of mammals, yet its
underlying molecular mechanisms remain largely underexplored. Here, we compared the …

Aging is a major risk factor for multiple diseases. Understanding the underlying mechanisms
of aging would help to delay and prevent age-associated diseases. Short-lived model …