Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Calreticulin (CALR) is an endoplasmic reticulum (ER)-resident protein involved in a
spectrum of cellular processes. In healthy cells, CALR operates as a chaperone and Ca2+ …

Dendritic cells (DCs) contribute a small fraction of the tumor microenvironment but are
emerging as an essential antitumor component based on their ability to foster T cell …

While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic
metabolism of all the cellular compartments that form the tumor microenvironment (TME) …

Despite great success in cancer immunotherapy, immune checkpoint-targeting drugs are not
the most popular weapon in the armory of cancer therapy. Accumulating evidence suggests …

Dendritic cells (DC) are key sentinels of the host immune response with an important role in
linking innate and adaptive immunity and maintaining tolerance. There is increasing …

CD24 is a highly glycosylated protein with a small protein core that is linked to the plasma
membrane via a glycosyl‐phosphatidylinositol anchor. CD24 is primarily expressed by …

Cancer treatment has rapidly entered the age of immunotherapy, and it is becoming clear
that the effective therapy of established tumors necessitates rational multi-combination …

Despite unprecedented responses of some cancers to immune checkpoint blockade (ICB)
therapies, the application of checkpoint inhibitors in pancreatic cancer has been …