[HTML][HTML] History and future perspectives on the discipline of quantitative systems pharmacology modeling and its applications
K Azer, CD Kaddi, JS Barrett, JPF Bai… - Frontiers in …, 2021 - frontiersin.org
Mathematical biology and pharmacology models have a long and rich history in the fields of
medicine and physiology, impacting our understanding of disease mechanisms and the …
medicine and physiology, impacting our understanding of disease mechanisms and the …
Next-generation genome-scale metabolic modeling through integration of regulatory mechanisms
Genome-scale metabolic models (GEMs) are powerful tools for understanding metabolism
from a systems-level perspective. However, GEMs in their most basic form fail to account for …
from a systems-level perspective. However, GEMs in their most basic form fail to account for …
Tuberculosis: an update on pathophysiology, molecular mechanisms of drug resistance, newer anti-TB drugs, treatment regimens and host-directed therapies
P Borah, PK Deb, KN Venugopala… - Current Topics in …, 2021 - ingentaconnect.com
Human tuberculosis (TB) is primarily caused by Mycobacterium tuberculosis (Mtb) that
inhabits inside and amidst immune cells of the host with adapted physiology to regulate …
inhabits inside and amidst immune cells of the host with adapted physiology to regulate …
Structure-aware Mycobacterium tuberculosis functional annotation uncloaks resistance, metabolic, and virulence genes
Accurate and timely functional genome annotation is essential for translating basic pathogen
research into clinically impactful advances. Here, through literature curation and structure …
research into clinically impactful advances. Here, through literature curation and structure …
Transcriptional regulator-induced phenotype screen reveals drug potentiators in Mycobacterium tuberculosis
Transposon-based strategies provide a powerful and unbiased way to study the bacterial
stress response,,,,,,–, but these approaches cannot fully capture the complexities of network …
stress response,,,,,,–, but these approaches cannot fully capture the complexities of network …
[HTML][HTML] 工业微生物代谢网络模型的研究进展及应用
张晨阳， 武耀康， 徐显皓， 吕雪芹， 李江华， 堵国成… - 生物工程 …, 2021 - cjb.ijournals.cn
基因组规模代谢网络(Genome-scale metabolic network model, GSMM)
是工业微生物菌株定向改造过程中一种极为重要的指导性工具, 有助于研究者快速获取特定性状 …
是工业微生物菌株定向改造过程中一种极为重要的指导性工具, 有助于研究者快速获取特定性状 …
PathExt: a general framework for path-based mining of omics-integrated biological networks
Motivation Transcriptomes are routinely used to prioritize genes underlying specific
phenotypes. Current approaches largely focus on differentially expressed genes (DEGs) …
phenotypes. Current approaches largely focus on differentially expressed genes (DEGs) …
Quantitative prediction of conditional vulnerabilities in regulatory and metabolic networks using PRIME
SRC Immanuel, ML Arrieta-Ortiz, RA Ruiz… - npj Systems Biology …, 2021 - nature.com
The ability of Mycobacterium tuberculosis (Mtb) to adopt heterogeneous physiological states
underlies its success in evading the immune system and tolerating antibiotic killing. Drug …
underlies its success in evading the immune system and tolerating antibiotic killing. Drug …
Quantitative prediction of conditional vulnerabilities in regulatory and metabolic networks of Mycobacterium tuberculosis
SRC Immanuel, ML Arrieta-Ortiz, RA Ruiz, M Pan… - BioRxiv, 2021 - biorxiv.org
The ability of Mycobacterium tuberculosis (Mtb) to adopt heterogeneous physiological
states, underlies its success in evading the immune system and tolerating antibiotic killing …
states, underlies its success in evading the immune system and tolerating antibiotic killing …
Collateral sensitivity to β-lactam drugs in drug-resistant tuberculosis is driven by the transcriptional wiring of BlaI operon genes
The evolution of resistance to one antimicrobial can result in enhanced sensitivity to another,
known as “collateral sensitivity.” This underexplored phenomenon opens new therapeutic …
known as “collateral sensitivity.” This underexplored phenomenon opens new therapeutic …