Importance Crohn disease, a chronic gastrointestinal inflammatory disease, is increasing in
incidence and prevalence in many parts of the world. Uncontrolled inflammation leads to …

Anti-tumour necrosis factor (TNF) antibodies have been widely used for approximately 25
years now. The first clinical observations in patients with refractory Crohn's disease rapidly …

The incidence and prevalence of Crohn's disease (CD) is rising globally. Patients with
moderate to severe CD are at high risk for needing surgery and hospitalization and for …

Background & Aims Patients with Crohn's disease (CD) or ulcerative colitis (UC) often
receive combination therapy with an immunomodulator and tumor necrosis factor …

Background and aims Immunogenicity with formation of anti-drug antibodies (ADA) to
biologics is an important reason for treatment failure in inflammatory bowel disease (IBD) …

Background Ustekinumab has been recently approved for the treatment of moderately to
severely active ulcerative colitis (UC). The registry trials for ustekinumab in UC …

Aim The literature regarding monoclonal antibodies and increased postoperative
complications in inflammatory bowel disease remains controversial. There have been no …

Therapeutic drug monitoring (TDM) is the measurement of drug and antidrug antibody
concentrations in individuals to guide treatment decisions. In patients with Crohn disease …

Crohn's disease (CD) is a chronic disorder characterized by full thickness patchy
inflammation of the gastrointestinal tract. The pathogenesis is multifactorial and involves …

Psoriasis, an inflammatory disorder of the skin, is associated with an increased risk of
systemic diseases, such as psoriatic arthritis, psychiatric disorders, malignancy, and …