More than four decades have passed since the first example of a light-activated (caged)
compound was described. In the intervening years, a large number of light-responsive …

A vast majority of cancer deaths occur as a result of metastasis. Unfortunately, effective
treatments for metastases are currently lacking due to the difficulty of selectively targeting …

Mitochondrial DNA double-strand breaks (mtDSBs) are toxic lesions that compromise the
integrity of mitochondrial DNA (mtDNA) and alter mitochondrial function. Communication …

Although radiotherapy has been used for over a century to locally control tumor growth,
alone it rarely induces an abscopal response or systemic antitumor immunity capable of …

Immunotherapies are a promising advance in cancer treatment. However, because only a
subset of cancer patients benefits from these treatments it is important to find mechanisms …

Breast cancer has historically been a disease for which immunotherapy was largely
unavailable. Recently, the use of immune checkpoint inhibitors (ICIs) in combination with …

Radiation therapy (RT) in some cases results in a systemic anticancer response known as
the abscopal effect. Multiple hypotheses support the role of immune activation initiated by …

Aim To report early findings from a phase II trial of high-dose radiotherapy (HD-RT) with or
without low-dose RT (LD-RT) for metastatic cancer. Methods Eligible patients had metastatic …

Background A combination of programmed cell death protein‐1 (PD‐1)/programmed cell
death ligand‐1 (PD‐L1) inhibitors and radiotherapy (RT) is increasingly being used to treat …

Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment over the past
decade. However, although the immune landscape suggests a strong rationale for the use of …