Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …

Chronic spontaneous urticaria is characterized by a perivascular non-necrotizing cellular
infiltrate around small venules of the skin. It consists primarily of CD4 (+) lymphocytes, a …

Systemic lupus erythematosus is a rare lifelong multi-systemic autoimmune condition.
Juvenile-onset SLE (JSLE) is recognized to have a more active disease course when …

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease. The disease is
characterized by activation and dysregulation of both the innate and the adaptive immune …

There are regular reports of extrapulmonary infections and manifestations related to the
ongoing COVID-19 pandemic. Coronaviruses are potentially neurotropic, which renders …

Introduction: Systemic lupus erythematosus [SLE] is a chronic, autoimmune condition
characterized by the formation of autoantibodies directed against nuclear components and …

Autoreactive T cells play a crucial role in the pathogenesis of systemic lupus erythematosus
(SLE). TGF-β type I receptor (TGFβRI) is pivotal in determining T cell activation. Here, we …

Abstract Interleukin (IL)-6 is a pleiotropic cytokine that is involved in the pathogenesis of
various rheumatic diseases. Direct inhibition of the IL-6 pathway by an anti-IL-6 receptor or …

Desensitization (DES) allows kidney transplantation for highly HLA-sensitized subjects. Due
to the central role of IL-6 in the immunological response, tocilizumab may improve DES …

Background. Highly HLA–sensitized kidney transplant candidates are difficult to desensitize,
which reduces their chances of receiving a transplant. Methods. We administered …