Combating mosquito-borne diseases using genetic control technologies
Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …
burdens. Unfortunately, current control methods based on insecticides and environmental …
CRISPR-Cas and its wide-ranging applications: From human genome editing to environmental implications, technical limitations, hazards and bioethical issues
R Piergentili, A Del Rio, F Signore, F Umani Ronchi… - Cells, 2021 - mdpi.com
The CRISPR-Cas system is a powerful tool for in vivo editing the genome of most organisms,
including man. During the years this technique has been applied in several fields, such as …
including man. During the years this technique has been applied in several fields, such as …
Suppressing mosquito populations with precision guided sterile males
The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow
fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually …
fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually …
Double drives and private alleles for localised population genetic control
K Willis, A Burt - PLoS Genetics, 2021 - journals.plos.org
Synthetic gene drive constructs could, in principle, provide the basis for highly efficient
interventions to control disease vectors and other pest species. This efficiency derives in part …
interventions to control disease vectors and other pest species. This efficiency derives in part …
Engineering the composition and fate of wild populations with gene drive
BA Hay, G Oberhofer, M Guo - Annual Review of Entomology, 2021 - annualreviews.org
Insects play important roles as predators, prey, pollinators, recyclers, hosts, parasitoids, and
sources of economically important products. They can also destroy crops; wound animals; …
sources of economically important products. They can also destroy crops; wound animals; …
Split versions of Cleave and Rescue selfish genetic elements for measured self limiting gene drive
G Oberhofer, T Ivy, BA Hay - PLoS genetics, 2021 - journals.plos.org
Gene drive elements promote the spread of linked traits, providing methods for changing the
composition or fate of wild populations. Drive mechanisms that are self-limiting are attractive …
composition or fate of wild populations. Drive mechanisms that are self-limiting are attractive …
Engineered reproductively isolated species drive reversible population replacement
Engineered reproductive species barriers are useful for impeding gene flow and driving
desirable genes into wild populations in a reversible threshold-dependent manner …
desirable genes into wild populations in a reversible threshold-dependent manner …
Expanding the Toolkit for Genome Editing in a Disease Vector, Aedes aegypti: Transgenic Lines Expressing Cas9 and Single Guide RNA Induce Efficient …
CRISPR-Cas9 mediated genome editing methods are being used for the analysis of gene
function. However, it is hard to identify gene knockout mutants for genes whose knockout …
function. However, it is hard to identify gene knockout mutants for genes whose knockout …
Field Trials of Gene Drive Mosquitoes: Lessons from Releases of Genetically Sterile Males and Wolbachia-infected Mosquitoes
JM Marshall, VN Vásquez - … Modified and other Innovative Vector Control …, 2021 - Springer
The discovery of CRISPR-based gene editing and its application to homing-based gene
drive has been greeted with excitement, for its potential to control mosquito-borne diseases …
drive has been greeted with excitement, for its potential to control mosquito-borne diseases …
[图书][B] Genome Editing Tools and Gene Drives: A Brief Overview
R Mudziwapasi, R Chekera, CZ Ncube, I Shoko… - 2021 - taylorfrancis.com
Genome-editing methods are becoming routine tools for molecular and cell biologists. Such
tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the …
tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the …