A long way to go: caspase inhibitors in clinical use

S Dhani, Y Zhao, B Zhivotovsky - Cell death & disease, 2021 - nature.com
Caspases are an evolutionary conserved family of cysteine-dependent proteases that are
involved in many vital cellular processes including apoptosis, proliferation, differentiation …

Long non-coding RNAs in pathogenesis of neurodegenerative diseases

S Zhou, X Yu, M Wang, Y Meng, D Song… - Frontiers in Cell and …, 2021 - frontiersin.org
Emerging evidence addresses the link between the aberrant epigenetic regulation of gene
expression and numerous diseases including neurological disorders, such as Alzheimer's …

[HTML][HTML] Toxicity of different zinc oxide nanomaterials and dose-dependent onset and development of Parkinson's disease-like symptoms induced by zinc oxide …

M Jin, N Li, W Sheng, X Ji, X Liang, B Kong, P Yin… - Environment …, 2021 - Elsevier
With the increasing applications in various fields, the release and accumulation of zinc oxide
(ZnO) nanomaterials ultimately lead to unexpected consequences to environment and …

Novel mechanistic insights towards the repositioning of alogliptin in Parkinson's disease

MM Safar, NF Abdelkader, E Ramadan, MA Kortam… - Life Sciences, 2021 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disease that impairs people's
lives tremendously. The development of innovative treatment modalities for PD is a …

TRAIL mediates neuronal death in AUD: a link between neuroinflammation and neurodegeneration

L Qin, J Zou, A Barnett, RP Vetreno, FT Crews… - International journal of …, 2021 - mdpi.com
Although the cause of progressive neurodegeneration is often unclear, neuronal death can
occur through several mechanisms. In conditions such as Alzheimer's or alcohol use …

Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB

TW Chou, NP Chang, M Krishnagiri, AP Patel… - Cell Death & …, 2021 - nature.com
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the death of
midbrain dopamine neurons. The pathogenesis of PD is poorly understood, though …

Serum miR-214 serves as a biomarker for prodromal Parkinson's disease

L Li, J Ren, C Pan, Y Li, J Xu, H Dong… - Frontiers in Aging …, 2021 - frontiersin.org
Circulating microRNAs (miRNAs) have been proposed to be accessible biomarkers for
Parkinson's disease (PD). However, there is a lack of known miRNAs that can serve as …

Long non-coding RNAs in Parkinson's disease

C Xin, J Liu - Neurochemical research, 2021 - Springer
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder and is
associated with a range of motor and non-motor clinical symptoms. The underlying …

Inflammation and regulatory T cell genes are differentially expressed in peripheral blood mononuclear cells of Parkinson's disease patients

Z Karaaslan, ÖT Kahraman, E Şanlı, HA Ergen… - Scientific reports, 2021 - nature.com
Our aim was to identify the differentially expressed genes (DEGs) in peripheral blood
mononuclear cells (PBMC) of Parkinson's disease (PD) patients and healthy controls by …

LncRNA SNHG1 promotes neuronal injury in Parkinson's disease cell model by miR-181a-5p/CXCL12 axis

H Wang, X Wang, Y Zhang, J Zhao - Journal of molecular histology, 2021 - Springer
Small molecule RNA host gene 1 (SNHG1) has been found to be an important regulator in
the neurotoxicity of Parkinson's disease (PD). However, the underlying molecular …