Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis
S Hou, X Yang, Y Tong, Y Yang, Q Chen, B Wan… - European journal of …, 2021 - Elsevier
Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein
kinase (MAPK) family, is implicated in many human diseases. Here, we describe the …
kinase (MAPK) family, is implicated in many human diseases. Here, we describe the …
A computational analysis of the binding free energies of apoptosis signal-regulating kinase 1 inhibitors from different chemotypes
GP Volynets, LV Pletnova, VM Sapelkin… - Molecular …, 2021 - Taylor & Francis
Apoptosis signal-regulating kinase 1 (ASK1) has recently emerged as an attractive
molecular target for pharmaceutical intervention. Several classes of small-molecular ASK1 …
molecular target for pharmaceutical intervention. Several classes of small-molecular ASK1 …