The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by virtually every
cell type. EVs have diverse biological activities, ranging from roles in development and …

Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal
malignant disease, has a complex but unknown tumor ecosystem. Here, we investigate the …

Prostate cancer (PCa) is the most common solid tumor in men. While patients with local PCa
have better prognostic survival, patients with metastatic PCa have relatively high mortality …

Multiple lines of evidence are indicating that cancer development and malignant
progression are not exclusively epithelial cancer cell-autonomous processes but may also …

Cancer promotion, development, and malignant transformation is greatly influenced by cell-
to-cell interactions in a complex tissue microenvironment. Cancer and stromal cells secrete …

The tumor microenvironment (TME) is a complex network of cellular organization consisting
of fibroblasts, adipocytes, pericytes, immune cells endothelial cells, and extracellular matrix …

Cancer-associated fibroblasts (CAFs) are the main stromal components of cancer,
representing a group of heterogeneous cells. Many studies indicate that CAFs promote …

The transmission of information between tumor cells and other cell types in the tumor
microenvironment plays an important role in tumor metastasis and is critically modulated by …

Head and neck squamous cell carcinoma (HNSCC) is one of the main malignant tumours
affecting human health, mainly due to delayed diagnosis and high invasiveness …