[HTML][HTML] Changes in glutathione content in liver diseases: an update

M Vairetti, LG Di Pasqua, M Cagna, P Richelmi… - Antioxidants, 2021 - mdpi.com
Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important
thiol reducing agent involved in the modulation of redox processes. It has also been …

Risk associated with the use of selected ingredients in food supplements

K Jędrejko, J Lazur, B Muszyńska - Chemistry & Biodiversity, 2021 - Wiley Online Library
This review focuses on four new product categories of food supplements: pre‐workout, fat
burner/thermogenic, brain/cognitive booster, and hormone/testosterone booster. Many food …

[HTML][HTML] Agmatine as a novel candidate for rapid-onset antidepressant response

AP Valverde, A Camargo… - World journal of …, 2021 - ncbi.nlm.nih.gov
Major depressive disorder (MDD) is a disabling and highly prevalent mood disorder as well
as a common cause of suicide. Chronic stress, inflammation, and intestinal dysbiosis have …

Possible involvement of agmatine in neuropharmacological actions of metformin in diabetic mice

N Kotagale, S Rahangdale, A Borkar, K Singh… - European journal of …, 2021 - Elsevier
The risk of psychiatric and neurological disorders is significantly higher in patients with
diabetes mellitus. Diabetic patients are more susceptible to depression, anxiety and memory …

Agmatine requires GluN2B-containing NMDA receptors to inhibit the development of neuropathic pain

CD Peterson, KF Kitto, H Verma, K Pflepsen… - Molecular …, 2021 - journals.sagepub.com
A decarboxylated form of L-arginine, agmatine, preferentially antagonizes NMDArs
containing Glun2B subunits within the spinal cord and lacks motor side effects commonly …

[HTML][HTML] Role of agmatine in the application of neural progenitor cell in central nervous system diseases: therapeutic potentials and effects

R Kosonen, S Barua, JY Kim… - Anatomy & Cell …, 2021 - synapse.koreamed.org
Agmatine, the primary decarboxylation product of L-arginine, generated from arginine
decarboxylase. Since the discovery of agmatine in the mammalian brain in the 1990s, an …

Effects of sex and estrous cycle on the brain and plasma arginine metabolic profile in rats

J Zhang, Y Jing, H Zhang, P Liu - Amino Acids, 2021 - Springer
Abstract l-arginine is a versatile amino acid with a number of bioactive metabolites.
Increasing evidence implicates altered arginine metabolism in the aging and …

[HTML][HTML] Crystal Structure of Escherichia coli Agmatinase: Catalytic Mechanism and Residues Relevant for Substrate Specificity

P Maturana, MS Orellana, SM Herrera… - International Journal of …, 2021 - mdpi.com
Agmatine is the product of the decarboxylation of L-arginine by the enzyme arginine
decarboxylase. This amine has been attributed to neurotransmitter functions, anticonvulsant …

Involvement of agmatine in antidepressant-like effect of HMG-CoA reductase inhibitors in mice

S Rahangdale, R Fating, M Gajbhiye, M Kapse… - European Journal of …, 2021 - Elsevier
Hydroxy-3-methyl-glutaryl-co-enzyme–A (HMG-CoA) reductase inhibitors (statins) are
popularly used for the treatment of obesity and hypercholesterolemia with established safety …

The contributions of metabolomics in the discovery of new therapeutic targets in Alzheimer's disease

R Altiné‐Samey, D Antier, S Mavel… - Fundamental & …, 2021 - Wiley Online Library
Alzheimer's disease (AD) leads to the progressive loss of memory and other cognitive
functions. It is the most common form of dementia in the elderly and has become a major …