Myeloid malignancies with 5q and 7q deletions are associated with extreme genomic complexity, biallelic TP53 variants, and very poor prognosis

BA Pitel, N Sharma, C Zepeda-Mendoza… - Blood cancer …, 2021 - nature.com
Dear Editor, Acute myeloid leukemia (AML) is an aggressive myeloid neoplasm
representing the most common type of acute leukemia in adults 1, 2. AML is classified into …

Delineation of molecular lesions in acute myeloid leukemia patients at diagnosis: integrated next generation sequencing and cytogenomic studies

SM Papuc, A Erbescu, D Cisleanu, D Ozunu, C Enache… - Genes, 2021 - mdpi.com
Acute myeloid leukemia (AML) is a heterogeneous disorder characterized by a wide range
of genetic defects. Cytogenetics, molecular and genomic technologies have proved to be …

Acquisition of a rare NUP98-BPTF fusion gene associated with recurrence of acute myeloid leukemia

K Kawaguchi, S Azumi, Y Itakura… - Pediatric blood & …, 2021 - pubmed.ncbi.nlm.nih.gov
Acquisition of a rare NUP98-BPTF fusion gene associated with recurrence of acute myeloid
leukemia Acquisition of a rare NUP98-BPTF fusion gene associated with recurrence of acute …

The diverse landscape of fusion transcripts in 25 different hematological entities

C Haferlach, W Walter, A Stengel… - Leukemia & …, 2021 - Taylor & Francis
Genomic alterations are a hallmark of hematological neoplasms and comprise small
nucleotide variants, copy number alterations, and structural variants (SV). The latter can …