The activity‐dependent fusion, retrieval and recycling of synaptic vesicles is essential for the
maintenance of neurotransmission. Until relatively recently it was believed that most …

Exocytosis is a Ca2+-regulated process that requires the participation of Ca2+ sensors. In
the 1980s, two classes of Ca2+-binding proteins were proposed as putative Ca2+ sensors …

During ongoing presynaptic action potential (AP) firing, transmitter release is limited by the
availability of release-ready synaptic vesicles (SVs). The rate of SV recruitment (SVR) to …

Munc13-1 plays a central role in neurotransmitter release through its conserved C-terminal
region, which includes a diacyglycerol (DAG)-binding C1 domain, a Ca2+/PIP2-binding C2B …

In contrast to their postsynaptic counterparts, the contributions of activity-dependent
cytoskeletal signaling to presynaptic plasticity remain controversial and poorly understood …

The concentration of calcium ions in presynaptic terminals regulates transmitter release, but
underlying mechanisms have remained unclear. Here we review recent studies that shed …

Post-tetanic potentiation (PTP) is a form of short-term plasticity that lasts for tens of seconds
following a burst of presynaptic activity. It has been proposed that PTP arises from protein …

An action potential triggers neurotransmitter release from synaptic vesicles docking to a
specialized release site of the presynaptic plasma membrane, the active zone. The active …

Before fusion, synaptic vesicles (SVs) pause at discrete release/docking sites. During
repetitive stimulation, the probability of site occupancy changes following SV fusion and …

For decades, a role for the Ca2+-binding protein calmodulin (CaM) in Ca2+-dependent
presynaptic modulation of synaptic transmission has been recognized. Here, we …