Cytokines: from clinical significance to quantification
Cytokines are critical mediators that oversee and regulate immune and inflammatory
responses via complex networks and serve as biomarkers for many diseases. Quantification …
responses via complex networks and serve as biomarkers for many diseases. Quantification …
[HTML][HTML] Antimicrobial peptides and cell-penetrating peptides for treating intracellular bacterial infections
Bacterial infections caused by intracellular pathogens are difficult to control. Conventional
antibiotic therapies are often ineffective, as high doses are needed to increase the number …
antibiotic therapies are often ineffective, as high doses are needed to increase the number …
[HTML][HTML] Mechanisms of immunotoxicity: stressors and evaluators
The immune system defends the body against certain tumor cells and against foreign agents
such as fungi, parasites, bacteria, and viruses. One of its main roles is to distinguish …
such as fungi, parasites, bacteria, and viruses. One of its main roles is to distinguish …
[HTML][HTML] Electrochemical biosensors for cytokine profiling: recent advancements and possibilities in the near future
Cytokines are soluble proteins secreted by immune cells that act as molecular messengers
relaying instructions and mediating various functions performed by the cellular counterparts …
relaying instructions and mediating various functions performed by the cellular counterparts …
[HTML][HTML] Therapeutic potential of ursolic acid in cancer and diabetic neuropathy diseases
Ursolic acid (UA) is a pentacyclic triterpenoid frequently found in medicinal herbs and plants,
having numerous pharmacological effects. UA and its analogs treat multiple diseases …
having numerous pharmacological effects. UA and its analogs treat multiple diseases …
Immunoengineering approaches for cytokine therapy
Since the discovery of cytokines, much effort has been put forth to achieve therapeutic
translation for treatment of various diseases, including cancer and autoimmune diseases …
translation for treatment of various diseases, including cancer and autoimmune diseases …
Engineered cytokines for cancer and autoimmune disease immunotherapy
B Uricoli, LA Birnbaum, P Do, JM Kelvin… - Advanced …, 2021 - Wiley Online Library
Cytokine signaling is critical to a range of biological processes including cell development,
tissue repair, aging, and immunity. In addition to acting as key signal mediators of the …
tissue repair, aging, and immunity. In addition to acting as key signal mediators of the …
Therapeutic advantage of Tyk2 inhibition for treating autoimmune and chronic inflammatory diseases
R Muromoto, K Shimoda, K Oritani… - Biological and …, 2021 - jstage.jst.go.jp
Abstract Tyrosine kinase 2 (Tyk2) is a member of the Janus family of protein tyrosine kinases
(Jaks). Tyk2 associates with interferon (IFN)-α, IFN-β, interleukin (IL)-6, IL-10, IL-12, and IL …
(Jaks). Tyk2 associates with interferon (IFN)-α, IFN-β, interleukin (IL)-6, IL-10, IL-12, and IL …
Maternal chronic conditions and risk of cerebral palsy in offspring: a national cohort study
METHODS: We conducted a prospective cohort study of Norwegian children born in 1990–
2012 and surviving to 2 years of age. Information on maternal chronic conditions during …
2012 and surviving to 2 years of age. Information on maternal chronic conditions during …
[HTML][HTML] STAT3 determines IL-4 signalling outcomes in naive T cells
LP Deimel, Z Li, S Roy, C Ranasinghe - Scientific reports, 2021 - nature.com
IL-4 production is associated with low-avidity, poorly cytotoxic T cell induction that
contributes to viral immune evasion and the failure of T cell-based vaccines. Yet, the precise …
contributes to viral immune evasion and the failure of T cell-based vaccines. Yet, the precise …