[HTML][HTML] Targeted and immuno-based therapies in sarcoma: mechanisms and advances in clinical trials

F Tang, Y Tie, YQ Wei, CQ Tu, XW Wei - Biochimica et Biophysica Acta …, 2021 - Elsevier
Sarcomas represent a distinct group of rare malignant tumors with high heterogeneity.
Limited options with clinical efficacy for the metastatic or local advanced sarcoma existed …

Candidate biomarkers for specific intraoperative near-infrared imaging of soft tissue sarcomas: a systematic review

Z Rijs, AN Shifai, SE Bosma, PJK Kuppen… - Cancers, 2021 - mdpi.com
Simple Summary Near-infrared imaging of tumors during surgery facilitates the oncologic
surgeon to distinguish malignant from healthy tissue. The technique is based on fluorescent …

FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation

O Gultekin, J Gonzalez-Molina, E Hardell… - NPJ precision …, 2021 - nature.com
Uterine sarcomas are rare but deadly malignancies without effective treatment.
Immunotherapy is a promising new approach to treat these tumors but has shown …

[HTML][HTML] The mutational repertoire of uterine sarcomas and carcinosarcomas in a Brazilian cohort: A preliminary study

LT da Costa, LG Dos Anjos, LT Kagohara, GT Torrezan… - Clinics, 2021 - Elsevier
OBJECTIVES: The present study aimed to contribute to the catalog of genetic mutations
involved in the carcinogenic processes of uterine sarcomas (USs) and carcinosarcomas …

Activation of the PI3K-AKT-mTOR cascade in uterine leiomyosarcoma: a retrospective study of 31 patients

OA Rozonova, EV Artamonova… - Journal of Modern …, 2021 - modernonco.orscience.ru
Background. Taking into account the literature data, the activation of the PI3K-AKT-mTOR
cascade plays a role in the development of leiomyosarcoma (LMS), and the expression of …

Regulatory FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation

O Gultekin, J Gonzalez-Molina, E Hardell… - bioRxiv, 2021 - biorxiv.org
Purpose Uterine sarcomas are rare but deadly malignancies without effective treatment. The
goal of this study was to characterize and identify potential mechanisms underlying …

[HTML][HTML] Активация каскада PI3K-AKT-mTOR при лейомиосаркоме матки

ОА Розонова, ЕВ Артамонова, НА Козлов… - Современная …, 2021 - cyberleninka.ru
Обоснование. По литературным данным, активация каскада PI3K-AKT-mTOR играет
роль в развитии лейомиосаркомы (ЛМС), а экспрессия маркеров данного сигнального …