Evolutionary trajectory of SARS-CoV-2 and emerging variants

J Singh, P Pandit, AG McArthur, A Banerjee… - Virology journal, 2021 - Springer
The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 …

Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants

D Gupta, P Sharma, M Singh, M Kumar… - Cellular and Molecular …, 2021 - Springer
Since the emergence of the first case of coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus (SARS-CoV-2), the viral genome has …

[HTML][HTML] Structural modeling of the SARS-CoV-2 spike/human ACE2 complex interface can identify high-affinity variants associated with increased transmissibility

HH Gan, A Twaddle, B Marchand… - Journal of Molecular …, 2021 - Elsevier
The COVID-19 pandemic has triggered concerns about the emergence of more infectious
and pathogenic viral strains. As a public health measure, efficient screening methods are …

Interactions of the receptor binding domain of SARS-CoV-2 variants with hACE2: Insights from molecular docking analysis and molecular dynamic simulation

I Celik, R Yadav, Z Duzgun, S Albogami… - Biology, 2021 - mdpi.com
Simple Summary Since the onset of the COVID-19 pandemic in late 2019, SARS-CoV-2 has
evolved via genetic changes, resulting in numerous variants of concern (VOCs) and interest …

Emergence and spread of SARS-CoV-2 lineage B. 1.620 with variant of concern-like mutations and deletions

G Dudas, SL Hong, BI Potter… - Nature …, 2021 - nature.com
Abstract Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance
initiatives, have emerged during the pandemic following unprecedented reductions in …

Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates

B Schrörs, P Riesgo-Ferreiro, P Sorn, R Gudimella… - PLoS …, 2021 - journals.plos.org
Due to the widespread of the COVID-19 pandemic, the SARS-CoV-2 genome is evolving in
diverse human populations. Several studies already reported different strains and an …

[HTML][HTML] Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay

E Lopez, ER Haycroft, A Adair, FL Mordant, MT O'Neill… - JCI insight, 2021 - ncbi.nlm.nih.gov
The SARS-CoV-2 receptor binding domain (RBD) is both the principal target of neutralizing
antibodies and one of the most rapidly evolving domains, which can result in the emergence …

Coronavirus disease (COVID-19) control between drug repurposing and vaccination: a comprehensive overview

AA Al-Karmalawy, R Soltane, A Abo Elmaaty… - Vaccines, 2021 - mdpi.com
Respiratory viruses represent a major public health concern, as they are highly mutated,
resulting in new strains emerging with high pathogenicity. Currently, the world is suffering …

Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B. 1.1. 28.4 and B. 1.1. 222 or B. 1.1 …

F Barona-Gómez, L Delaye… - Microbial …, 2021 - microbiologyresearch.org
Understanding the evolution of the SARS-CoV-2 virus in various regions of the world during
the Covid-19 pandemic is essential to help mitigate the effects of this devastating disease …

SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions

LFSM Timmers, JV Peixoto, RG Ducati, JFR Bachega… - Scientific reports, 2021 - nature.com
Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter
and, since then, is being monitored to understand how SARS-CoV-2 mutates and spreads …