In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

Fatigue is a complex phenomenon and an important health concern for many people with
chronic inflammatory rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis …

There is currently no approved treatment for primary Sjögren's syndrome, a disease that
primarily affects adult women. The difficulty in developing effective therapies is-in part …

Primary Sjögren syndrome (pSS) is a systemic autoimmune disease that is characterized by
a triad of symptoms that affect all patients (dryness, pain and fatigue). In addition, systemic …

Objectives No immunomodulatory drug has been approved for primary Sjögren's syndrome,
a systemic autoimmune disease affecting 0.1% of the population. To demonstrate the …

Objectives To evaluate efficacy and safety of abatacept in adults with active primary
Sjögren's syndrome (pSS) in a phase III, randomised, double-blind, placebo-controlled trial …

Detecting autoantibodies provides foundational information for the diagnosis of most
autoimmune diseases. An important pathophysiological distinction is whether …

Background Recent randomised controlled trials (RCTs) in primary Sjögren's syndrome
used the European League Against Rheumatism (EULAR) Sjögren's Syndrome Disease …

Abstract The classic Th1/Th2 dogma has been significantly reshaped since the subsequent
introduction of several new T helper cell subsets, among which the most intensively …

Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings,
but, behind these common features, there are different pathogenic mechanisms, immune …