Deciphering the principles and mechanisms by which gene activity orchestrates complex
cellular arrangements in multicellular organisms has far-reaching implications for research …

Spatial transcriptional profiling provides gene expression information within the important
anatomical context of tissue architecture. This approach is well suited to characterizing solid …

Spatial transcriptomic studies are becoming increasingly common and large, posing
important statistical and computational challenges for many analytic tasks. Here, we present …

Glioblastoma multiforme (GBM) is the most lethal primary brain tumor characterized by high
cellular and molecular heterogeneity, hypervascularization, and innate drug resistance …

The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in
a growing list of human diseases. CIC belongs to a large family of nuclear-encoded …

Spatially resolved RNA and protein molecular analyses have revealed unexpected
heterogeneity of cells. Metabolic analysis of individual cells complements these single-cell …

Spatial transcriptomics is now a mature technology, allowing to assay gene expression
changes in the histological context of complex tissues. A canonical analysis workflow starts …

Malignant tumor has become one of the major diseases that seriously endangers human
health. Numerous studies have demonstrated that tumor microenvironment (TME) is closely …

Metabolic reprogramming is a hallmark of malignancy. It implements profound metabolic
changes to sustain cancer cell survival and proliferation. Although the Warburg effect is a …

Non-small cell lung cancer (NSCLC) is one of the most common cancers globally and has a
5-year survival rate~ 20%. Immunotherapies have demonstrated long-term and durable …