Exploring tissue architecture using spatial transcriptomics
Deciphering the principles and mechanisms by which gene activity orchestrates complex
cellular arrangements in multicellular organisms has far-reaching implications for research …
cellular arrangements in multicellular organisms has far-reaching implications for research …
Applicability of spatial transcriptional profiling to cancer research
R Bassiouni, LD Gibbs, DW Craig, JD Carpten… - Molecular cell, 2021 - cell.com
Spatial transcriptional profiling provides gene expression information within the important
anatomical context of tissue architecture. This approach is well suited to characterizing solid …
anatomical context of tissue architecture. This approach is well suited to characterizing solid …
SPARK-X: non-parametric modeling enables scalable and robust detection of spatial expression patterns for large spatial transcriptomic studies
Spatial transcriptomic studies are becoming increasingly common and large, posing
important statistical and computational challenges for many analytic tasks. Here, we present …
important statistical and computational challenges for many analytic tasks. Here, we present …
Rapid 3D bioprinting of glioblastoma model mimicking native biophysical heterogeneity
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor characterized by high
cellular and molecular heterogeneity, hypervascularization, and innate drug resistance …
cellular and molecular heterogeneity, hypervascularization, and innate drug resistance …
The mitochondrial citrate carrier SLC25A1/CIC and the fundamental role of citrate in cancer, inflammation and beyond
R Mosaoa, A Kasprzyk-Pawelec, HR Fernandez… - Biomolecules, 2021 - mdpi.com
The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in
a growing list of human diseases. CIC belongs to a large family of nuclear-encoded …
a growing list of human diseases. CIC belongs to a large family of nuclear-encoded …
Spatially resolved 3D metabolomic profiling in tissues
Spatially resolved RNA and protein molecular analyses have revealed unexpected
heterogeneity of cells. Metabolic analysis of individual cells complements these single-cell …
heterogeneity of cells. Metabolic analysis of individual cells complements these single-cell …
SpatialDE2: fast and localized variance component analysis of spatial transcriptomics
I Kats, R Vento-Tormo, O Stegle - Biorxiv, 2021 - biorxiv.org
Spatial transcriptomics is now a mature technology, allowing to assay gene expression
changes in the histological context of complex tissues. A canonical analysis workflow starts …
changes in the histological context of complex tissues. A canonical analysis workflow starts …
Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment
Y Luo, S Yin, J Lu, S Zhou, Y Shao, X Bao… - Cancer Cell …, 2021 - Springer
Malignant tumor has become one of the major diseases that seriously endangers human
health. Numerous studies have demonstrated that tumor microenvironment (TME) is closely …
health. Numerous studies have demonstrated that tumor microenvironment (TME) is closely …
Targeting mitochondrial metabolism in prostate cancer with triterpenoids
K Mamouni, G Kallifatidis, BL Lokeshwar - International journal of …, 2021 - mdpi.com
Metabolic reprogramming is a hallmark of malignancy. It implements profound metabolic
changes to sustain cancer cell survival and proliferation. Although the Warburg effect is a …
changes to sustain cancer cell survival and proliferation. Although the Warburg effect is a …
[HTML][HTML] The Pandora's box of novel technologies that may revolutionize lung cancer
HS Rad, HS Rad, Y Shiravand, P Radfar, D Arpon… - Lung Cancer, 2021 - Elsevier
Non-small cell lung cancer (NSCLC) is one of the most common cancers globally and has a
5-year survival rate~ 20%. Immunotherapies have demonstrated long-term and durable …
5-year survival rate~ 20%. Immunotherapies have demonstrated long-term and durable …