DNA methylation in stress and depression: from biomarker to therapeutics

AJ Sales, FS Guimarães, SRL Joca - Acta Neuropsychiatrica, 2021 - cambridge.org
Epigenetic mechanisms such as DNA methylation (DNAm) have been associated with stress
responses and increased vulnerability to depression. Abnormal DNAm is observed in …

[HTML][HTML] A novel murine model to study the impact of maternal depression and antidepressant treatment on biobehavioral functions in the offspring

J Scarborough, FS Mueller, U Weber-Stadlbauer… - Molecular …, 2021 - nature.com
Antenatal psychopathology negatively affects obstetric outcomes and exerts long-term
consequences on the offspring's wellbeing and mental health. However, the precise …

[HTML][HTML] Epigenetics and Early Life Stress: Experimental Brood Size Affects DNA Methylation in Great Tits (Parus major)

B Sepers, JAM Erven, F Gawehns, VN Laine… - Frontiers in Ecology …, 2021 - frontiersin.org
Early developmental conditions are known to have life-long effects on an individual's
behavior, physiology and fitness. In altricial birds, a majority of these conditions, such as the …

Maternal stress during pregnancy affects activity, exploration and potential dispersal of daughters in an invasive fish

KE McGhee, AJ Barbosa, K Bissell, NA Darby… - Animal Behaviour, 2021 - Elsevier
Highlights•Maternal stress during pregnancy can affect offspring development.•We
manipulated exposure of pregnant mosquitofish to a predatory bass model.•Maternal stress …

The influence of maternal glucocorticoids on offspring phenotype in high-and low-risk environments

KJ MacLeod, T Langkilde, CP Venable… - Behavioral …, 2021 - academic.oup.com
Elevated maternal glucocorticoid levels during gestation can lead to phenotypic changes in
offspring via maternal effects. Although such effects have traditionally been considered …

Sex-specific maternal programming of corticosteroid-binding globulin by predator odour

S Abuaish, SG Lavergne, B Hing… - … of the Royal …, 2021 - royalsocietypublishing.org
Predation is a key organizing force in ecosystems. The threat of predation may act to
programme the endocrine hypothalamic–pituitary–adrenal axis during development to …

Diet-Epigenome interactions: epi-drugs modulating the epigenetic machinery during cancer prevention

FE Pehlivan - Epigenetics to Optogenetics: A New Paradigm in …, 2021 - books.google.com
The roles of diet and environment on health have been known since ancient times. Cancer
is both a genetic and an epigenetic disease and a complex interplay mechanism of genetic …

Role of brain-derived neurotrophic factor in shaping the behavioural response to environmental stressors

E Badowska-Szalewska, G Lietzau, J Moryś… - Folia …, 2021 - journals.viamedica.pl
Brain-derived neurotrophic factor (BDNF) is an important neurotrophin involved in an
integration of the brain activity in physiological and pathological conditions, with formation of …

Preconception parental predator stress induces brain and behavioral changes in offspring

S Bhattacharya - 2021 - research.library.mun.ca
Brain and behaviour are shaped by experience. Recent data suggest that experiences of the
parents can be 'passed-on'to alter brain and behavior of future generations. Stress during …

[HTML][HTML] Moderation of the transgenerational transference of antenatal stress-induced anxiety

O Burstein, N Simon, Y Simchon-Tenenbaum… - Translational …, 2021 - nature.com
Maternal stress has debilitating implications for both mother and child, including increased
risk for anxiety. The current COVID-19 pandemic escalates these phenomena, thus, urging …