Introduction In bone tissue, bone resorption by osteoclasts and bone formation by
osteoblasts are repeated continuously. Osteoclasts are multinucleated cells that derive from …

With the progress of the aging population, bone-related diseases such as osteoporosis and
osteoarthritis have become urgent problems. Recent studies have demonstrated the …

Osteoporosis is the most common metabolic skeletal disease. It is characterized by the
deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even …

Cell-cell communication is pivotal to guide embryo development, as well as to maintain adult
tissues homeostasis and control immune response. Among extracellular factors responsible …

Bone formation starts near the end of the embryonic stage of development and continues
throughout life during bone modeling and growth, remodeling, and when needed …

Emerging evidence in the literature describes a physical and functional association between
the neural and skeletal systems that forms a neuro-osteogenic network. This communication …

Osteoclastic bone resorption and osteoblastic bone formation/replenishment are closely
coupled in bone metabolism. Anabolic parathyroid hormone (PTH), which is commonly used …

Multiple myeloma (MM) is a neoplastic clonal proliferation of plasma cells in the bone
marrow microenvironment, characterized by overproduction of heavy-and light-chain …

Osteoclasts are specialized bone-resorbing cells that contribute to physiological bone
development and remodeling in bone metabolism throughout life. Abnormal production and …

Abstract Effect of the simultaneous hydrolysis of octacalcium phosphate (OCP) and poly
(lactic-co-glycolic acid)(PLGA) was investigated on its osteoconductivity. PLGA soaked in …