Glucocorticoids (GCs) are small lipid hormones produced by the adrenals that maintain
organismal homeostasis. Circadian and stress-induced changes in systemic GC levels …

Stringent spatiotemporal regulation of the wound healing process involving multiple cell
types is associated with epigenetic mechanisms of gene regulation, such as DNA …

CYP11A1, a member of the cytochrome P450 family, plays several key roles in the human
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …

Impaired wound healing associated with recurrent Staphylococcus aureus infection and
unresolved inflammation are hallmarks of nonhealing diabetic foot ulcers (DFUs). Perforin-2 …

The syndromes of mineralocorticoid excess describe a heterogeneous group of clinical
manifestations leading to endocrine hypertension, typically either through direct activation of …

Both acute and chronic cutaneous wounds are often difficult to treat due to the high-risk for
bacterial contamination. Once hospitalized, open wounds are at a high-risk for developing …

Elevated glucocorticoid (GC) activity may limit tumor immune response and immune
checkpoint inhibitor (ICI) efficacy. Adrenocortical carcinoma (ACC) provides a unique test …

Objective We investigated newly diagnosed patients with endogenous CS for molecular
changes in skin by biopsy before and a year after treatment of CS. Patients and methods 26 …

The relationship between stress and skin health has been documented since ancient times.
This chapter provides an overview of the biological pathways believed to play a role in the …

ABSTRACT Background: Glucocorticoids (GCs) are potent anti-inflammatory drugs whose
secretion is mediated and controlled by the hypothalamic-pituitary-adrenal axis. However …