Alkoxy radicals see the light: new paradigms of photochemical synthesis
Alkoxy radicals are highly reactive species that have long been recognized as versatile
intermediates in organic synthesis. However, their development has long been impeded due …
intermediates in organic synthesis. However, their development has long been impeded due …
Photocatalysis in the life science industry
L Candish, KD Collins, GC Cook, JJ Douglas… - Chemical …, 2021 - ACS Publications
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …
industry require access to mild and robust synthetic methodologies to systematically modify …
Trifluoromethyl Nonaflate: A Practical Trifluoromethoxylating Reagent and its Application to the Regio‐and Stereoselective Synthesis of Trifluoromethoxylated Alkenes
Z Lu, T Kumon, GB Hammond… - Angewandte Chemie …, 2021 - Wiley Online Library
The trifluoromethoxy group has elicited much interest among drug and agrochemical
discovery teams because of its unique properties. We developed trifluoromethyl …
discovery teams because of its unique properties. We developed trifluoromethyl …
Difluoromethyl Radical Triggered Tandem Reaction of N-Allyl Amides to Difluoromethylated β-Amino Alcohols by Photoredox Catalysis
WB Qin, W Xiong, YS Zhao, KZ Fu, L Su, GK Liu - Organic Letters, 2021 - ACS Publications
An elegant tandem reaction process for transferring N-allyl amide into CF2H-β-amino
alcohol is described. This approach proceeded smoothly under visible light irradiation in the …
alcohol is described. This approach proceeded smoothly under visible light irradiation in the …
Difluorocarbene‐Induced Ring‐Opening Difluoromethylation‐Halogenation of Cyclic (Thio)Ethers with TMSCF2X (X=Br, Cl)**
R Zhang, Q Li, Q Xie, C Ni, J Hu - Chemistry–A European …, 2021 - Wiley Online Library
The ring‐opening difluoromethylation‐halogenation of cyclic (thio) ethers is reported
through a simple strategy relying on carbon‐chalcogen bond activation with …
through a simple strategy relying on carbon‐chalcogen bond activation with …
Chemoselective desulfurization-fluorination/bromination of carbonofluoridothioates for the O-trifluoromethylation and O-bromodifluoromethylation of alcohols
J Liu, H Xiang, L Jiang, W Yi - Science China Chemistry, 2021 - Springer
Herein, a method for synthesizing various alkyl trifluoromethyl and alkyl bromodifluoromethyl
ethers using carbonofluoridothioates (R–OC (= S) F) as precursors has been described …
ethers using carbonofluoridothioates (R–OC (= S) F) as precursors has been described …
Transition Metal‐Free Regioselective Remote C− H Bond 2, 2, 2‐Trifluoroethoxylation of 8‐Aminoquinoline Derivatives at the C5 Position
Abstract The regioselective 2, 2, 2‐trifluoroethoxylation at the C5 position of amides derived
from the 8‐aminoquinoline has been developed. In the presence of PIDA, an unprecedented …
from the 8‐aminoquinoline has been developed. In the presence of PIDA, an unprecedented …
[PDF][PDF] 1.9 Oxygen-Centered Radicals
J Zhang, D Liu, Y Chen - Free Radicals: Fundamentals and …, 2021 - yiyunchen.sioc.ac.cn
Oxygen-centered radicals (R1O•) are important reactive intermediates in organic synthesis
and include carboxyl (R1= acyl), alkoxyl (R1= alkyl), phenoxyl (R1= aryl), and other related …
and include carboxyl (R1= acyl), alkoxyl (R1= alkyl), phenoxyl (R1= aryl), and other related …
Efficient Monofluoroalkylation of Thiophenols or Phenols with α-Bromo-α-Fluoroketones under Mild Conditions
Z Li, M Fang, J Wu, Y Liu, Y Liu, F Wu - Synthesis, 2021 - thieme-connect.com
An efficient nucleophilic substitution reaction between α-bromo-α-fluoroketones and
thiophenols or phenols is reported for the synthesis of α-fluoro-β-ketosulfides or α-fluoro-β …
thiophenols or phenols is reported for the synthesis of α-fluoro-β-ketosulfides or α-fluoro-β …