African trypanosomes are responsible for important diseases of humans and animals in sub-
Saharan Africa. The best-studied species is Trypanosoma brucei, which is characterized by …

Trypanosomiases and leishmaniases are neglected tropical diseases that have been
spreading to previously non-affected areas in recent years. Identification of new …

Developmental steps in the trypanosome life-cycle involve transition between replicative
and non-replicative forms specialised for survival in, and transmission between, mammalian …

The protozoan Trypanosoma cruzi almost invariably establishes life-long infections in
humans and other mammals, despite the development of potent host immune responses …

Highly selective gene expression is a key requirement for antigenic variation in several
pathogens, allowing evasion of host immune responses and maintenance of persistent …

AlphaFold2 and RoseTTAfold represent a transformative advance for predicting protein
structure. They are able to make very high-quality predictions given a high-quality alignment …

The mechanisms regulating the disassembly of branched actin networks formed by the
Arp2/3 complex still remain to be fully elucidated. In addition, the impact of Arp3 isoforms on …

Trypanosoma brucei is the causative agent of human sleeping sickness. The parasites'
variant surface glycoprotein (VSG) enables them to evade adaptive immunity via antigenic …

The long and complex Trypanosoma brucei development in the tsetse fly vector culminates
when parasites gain mammalian infectivity in the salivary glands. A key step in this process …

Nucleosomes composed of histones are the fundamental units around which DNA is
wrapped to form chromatin. Transcriptionally active euchromatin or repressive …