Citrate plays a central role in cancer cells' metabolism and regulation. Derived from
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …

Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of
glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed …

Destruction of tumor metabolism symbiosis is an attractive cancer treatment method which
targets tumor cells with little harm to normal cells. Yet, a single intervention strategy and poor …

Multiple lines of evidence are indicating that cancer development and malignant
progression are not exclusively epithelial cancer cell-autonomous processes but may also …

Cancer-associated fibroblasts (CAFs) are the main stromal components of cancer,
representing a group of heterogeneous cells. Many studies indicate that CAFs promote …

To adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …

Poor selectivity, potential systemic toxicity and drug resistance are the main challenges
associated with chemotherapeutic drugs. MCT1 and MCT4 and LAT1 play vital roles in …

Malignant glioma represents a fatal disease with a poor prognosis and development of
resistance mechanisms against conventional therapeutic approaches. The distinct tumor …

Abstract Treatment of locally advanced, unresectable head and neck squamous cell
carcinoma (HNSCC) often yields only modest results with radiochemotherapy (RCT) as …

Highlights•SLCs play a key part in the metabolically driven tumor growth and
metastasis.•SLCs can exert both tumor-promoting as well as suppressive functions in …