[HTML][HTML] Understanding the central role of citrate in the metabolism of cancer cells and tumors: an update
Citrate plays a central role in cancer cells' metabolism and regulation. Derived from
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …
[HTML][HTML] The metabolic fates of pyruvate in normal and neoplastic cells
EV Prochownik, H Wang - Cells, 2021 - mdpi.com
Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of
glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed …
glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed …
Zwitterion‐Based hydrogen sulfide nanomotors induce multiple acidosis in tumor cells by destroying tumor metabolic symbiosis
M Wan, Z Liu, T Li, H Chen, Q Wang… - Angewandte …, 2021 - Wiley Online Library
Destruction of tumor metabolism symbiosis is an attractive cancer treatment method which
targets tumor cells with little harm to normal cells. Yet, a single intervention strategy and poor …
targets tumor cells with little harm to normal cells. Yet, a single intervention strategy and poor …
[HTML][HTML] Determinants and functions of CAFs secretome during cancer progression and therapy
J Linares, JA Marín-Jiménez… - Frontiers in Cell and …, 2021 - frontiersin.org
Multiple lines of evidence are indicating that cancer development and malignant
progression are not exclusively epithelial cancer cell-autonomous processes but may also …
progression are not exclusively epithelial cancer cell-autonomous processes but may also …
[HTML][HTML] Cancer-associated fibroblasts suppress cancer development: the other side of the coin
Z Wang, Q Yang, Y Tan, Y Tang, J Ye… - Frontiers in cell and …, 2021 - frontiersin.org
Cancer-associated fibroblasts (CAFs) are the main stromal components of cancer,
representing a group of heterogeneous cells. Many studies indicate that CAFs promote …
representing a group of heterogeneous cells. Many studies indicate that CAFs promote …
[HTML][HTML] Cancer cell metabolism: Rewiring the mitochondrial hub
To adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …
Novel strategies to improve tumour therapy by targeting the proteins MCT1, MCT4 and LAT1
Y Wang, L Qin, W Chen, Q Chen, J Sun… - European Journal of …, 2021 - Elsevier
Poor selectivity, potential systemic toxicity and drug resistance are the main challenges
associated with chemotherapeutic drugs. MCT1 and MCT4 and LAT1 play vital roles in …
associated with chemotherapeutic drugs. MCT1 and MCT4 and LAT1 play vital roles in …
[HTML][HTML] The acidic brain—glycolytic switch in the microenvironment of malignant glioma
AM Reuss, D Groos, M Buchfelder… - International journal of …, 2021 - mdpi.com
Malignant glioma represents a fatal disease with a poor prognosis and development of
resistance mechanisms against conventional therapeutic approaches. The distinct tumor …
resistance mechanisms against conventional therapeutic approaches. The distinct tumor …
[HTML][HTML] Monocarboxylate transporter-1 (MCT1) protein expression in head and neck cancer affects clinical outcome
M Leu, J Kitz, Y Pilavakis, S Hakroush, HA Wolff… - Scientific reports, 2021 - nature.com
Abstract Treatment of locally advanced, unresectable head and neck squamous cell
carcinoma (HNSCC) often yields only modest results with radiochemotherapy (RCT) as …
carcinoma (HNSCC) often yields only modest results with radiochemotherapy (RCT) as …
Solute carriers as potential oncodrivers or suppressors: their key functions in malignant tumor formation
K Rashid, A Ahmad, L Liang, M Liu, Y Cui, T Liu - Drug discovery today, 2021 - Elsevier
Highlights•SLCs play a key part in the metabolically driven tumor growth and
metastasis.•SLCs can exert both tumor-promoting as well as suppressive functions in …
metastasis.•SLCs can exert both tumor-promoting as well as suppressive functions in …