Role of the constitutive androstane receptor (CAR) in human liver cancer
SDW Bae, R Nguyen, L Qiao, J George - Biochimica et Biophysica Acta …, 2021 - Elsevier
Background The constitutive androstane receptor (CAR) is a member of the nuclear receptor
superfamily (subfamily 1, group I, member 3, also known as NR1I3) that is almost exclusively …
superfamily (subfamily 1, group I, member 3, also known as NR1I3) that is almost exclusively …
Molecular mechanisms of the SLC13A5 gene transcription
Citrate is a crucial energy sensor that plays a central role in cellular metabolic homeostasis.
The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter …
The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter …
Metamizole is a moderate cytochrome P450 inducer via the constitutive androstane receptor and a weak inhibitor of CYP1A2
F Bachmann, U Duthaler… - Clinical …, 2021 - Wiley Online Library
Metamizole is an analgesic and antipyretic drug used intensively in certain countries.
Previous studies have shown that metamizole induces cytochrome (CYP) 2B6 and possibly …
Previous studies have shown that metamizole induces cytochrome (CYP) 2B6 and possibly …
Phenobarbital induces SLC13A5 expression through activation of PXR but not CAR in human primary hepatocytes
Phenobarbital (PB), a widely used antiepileptic drug, is known to upregulate the expression
of numerous drug-metabolizing enzymes and transporters in the liver primarily via activation …
of numerous drug-metabolizing enzymes and transporters in the liver primarily via activation …
Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells
HepaRG cells are increasingly accepted as model for human drug metabolism and other
hepatic functions. We used lentiviral transduction of undifferentiated HepaRG cells to deliver …
hepatic functions. We used lentiviral transduction of undifferentiated HepaRG cells to deliver …
[HTML][HTML] Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression following exposure to prototypical …
S Gerbal-Chaloin, P Briolotti… - Current Research in …, 2021 - Elsevier
The hepatic cytochrome p450's (CYP) are of major importance for the metabolism of
xenobiotics and knowledge about their regulation is crucial. This knowledge often originates …
xenobiotics and knowledge about their regulation is crucial. This knowledge often originates …
Deconvolution of cytochrome P450 induction mechanisms in HepaRG nuclear hormone receptor knockout cells
LC Preiss, R Liu, P Hewitt, D Thompson… - Drug Metabolism and …, 2021 - ASPET
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and PXR/CAR
knockout (KO) HepaRG cells, as well as a PXR reporter gene assay, were used to …
knockout (KO) HepaRG cells, as well as a PXR reporter gene assay, were used to …
Rôle du récepteur nucléaire CAR dans la pathogénèse dimorphique de la NAFLD (Non-Alcoholic Fatty Liver Disease), induite par un régime gras ou par l'exposition à …
F Oliviero - 2021 - theses.hal.science
Les maladies métaboliques sont en constante augmentation et représentent un problème
majeur de santé publique. Parmi celles-ci, la stéatose hépatique non-alcoolique (NAFLD) …
majeur de santé publique. Parmi celles-ci, la stéatose hépatique non-alcoolique (NAFLD) …