A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …

The cardiovascular (CV) benefit and safety of treating low testosterone conditions is a matter
of debate. Although testosterone deficiency has been linked to a rise in major adverse CV …

Congenital hypogonadotropic hypogonadism (CHH) is a clinically and genetically
heterogeneous congenital disease. Symptoms cover a wide spectrum from mild forms to …

Hypogonadotropic hypogonadism, which may be normosmic (nHH) or anosmic/hyposmic,
known as Kallmann syndrome (KS), is due to gonadotropin-releasing hormone deficiency …

Context Pubertal delay can be the clinical presentation of both idiopathic hypogonadotropic
hypogonadism (IHH) and self-limited delayed puberty (SLDP). Distinction between these …

Gonadotropin releasing hormone (GnRH) neurons are hypothalamic neuroendocrine cells
that control sexual reproduction. During embryonic development, GnRH neurons migrate …

Abstract Tachykinins (neurokinin A [NKA], neurokinin B [NKB], and substance P [SP]) are
important components of the neuroendocrine control of reproduction by direct stimulation of …

This chapter begins with a basic science update on the development of the female
reproductive system. This starts with sections on maturation of the neuroendocrine-ovarian …

Puberty is a key developmental milestone that marks an individual's maturation in several
ways including, but not limited to, reproductive maturation, changes in behaviors and neural …

In this chapter we discuss the development of the hypothalamic-pituitary-gonadal (HPG) axis
followed by a description of the physiology of the HPG axis, with a focus on its dynamic …