[HTML][HTML] Mitochondrial dysfunction and oxidative stress in Alzheimer's disease

A Misrani, S Tabassum, L Yang - Frontiers in aging neuroscience, 2021 - frontiersin.org
Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Mitochondrial quality control in kidney injury and repair

C Tang, J Cai, XM Yin, JM Weinberg… - Nature Reviews …, 2021 - nature.com
Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …

Role of mitochondrial quality surveillance in myocardial infarction: from bench to bedside

H Zhou, J Ren, S Toan, D Mui - Ageing Research Reviews, 2021 - Elsevier
Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …

[HTML][HTML] Neural stem cells traffic functional mitochondria via extracellular vesicles

L Peruzzotti-Jametti, JD Bernstock, CM Willis… - PLoS …, 2021 - journals.plos.org
Neural stem cell (NSC) transplantation induces recovery in animal models of central
nervous system (CNS) diseases. Although the replacement of lost endogenous cells was …

[HTML][HTML] Mitochondrial fission protein 1: emerging roles in organellar form and function in health and disease

UK Ihenacho, KA Meacham, MC Harwig… - Frontiers in …, 2021 - frontiersin.org
Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for
mitochondrial division or fission and subsequently determined to mediate human …

[HTML][HTML] Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial …

L Jiang, X Yin, YH Chen, Y Chen, W Jiang, H Zheng… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Reactive oxygen species (ROS) burst from mitochondrial complex I is considered
the critical cause of ischemia/reperfusion (I/R) injury. Ginsenoside Rb1 has been reported to …

[HTML][HTML] Pharmacological advances in mitochondrial therapy

A Singh, D Faccenda, M Campanella - EBioMedicine, 2021 - thelancet.com
Mitochondria play a vital role in cellular metabolism and are central mediator of intracellular
signalling, cell differentiation, morphogenesis and demise. An increasingly higher number of …

[HTML][HTML] Disentangling mitochondria in Alzheimer's disease

A Johri - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

[HTML][HTML] Mitochondria as key players in the pathogenesis and treatment of rheumatoid arthritis

SA Clayton, L MacDonald… - Frontiers in …, 2021 - frontiersin.org
Mitochondria are major energy-producing organelles that have central roles in cellular
metabolism. They also act as important signalling hubs, and their dynamic regulation in …

[HTML][HTML] Effects of mdivi-1 on neural mitochondrial dysfunction and mitochondria-mediated apoptosis in ischemia-reperfusion injury after stroke: A systematic review of …

NT Nhu, Q Li, Y Liu, J Xu, SY Xiao… - Frontiers in molecular …, 2021 - frontiersin.org
This systematic review sought to determine the effects of Mitochondrial division inhibitor-1
(Mdivi-1) on neural mitochondrial dysfunction and neural mitochondria-mediated apoptosis …