Patient‐derived cancer cells (PDCs) and patient‐derived xenografts (PDXs) are often used
as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell …

Tumor development and progression require chemical and mechanical cues derived from
cellular and non-cellular components in the tumor microenvironment, including the …

The metastatic process is arduous. Cancer cells must escape the confines of the primary
tumor, make their way into and travel through the circulation, then survive and proliferate in …

Breast cancer (BC) is the most frequently diagnosed malignancy among women globally.
Although mouse models have been critical in advancing the knowledge of BC tumorigenesis …

The growing need for personalized medicine for cancer patients has enhanced and
optimized the production of living tumor organoids that have become optimal preclinical …

Abstract Background Breast cancer Patient Derived Organoids (PDO) have been
demonstrated to be a reliable model to study cancer that promised to replace and reduce the …

Simple Summary Despite significant strides in multimodal therapy, cancers still rank within
the first three causes of death especially in industrial nations. A lack of individualized …

Organoids have complex three-dimensional structures that exhibit functionalities and feature
architectures similar to those of in vivo organs and are developed from adult stem cells …

BACKGROUND: Breast cancer is one of the most common malignant tumors in women. Its
incidence rate is increasing year by year and tends to be younger. It seriously threatens …

目的· 改进乳腺癌类器官培养传代方法, 建立富集肿瘤相关成纤维细胞(cancer associated
fibroblasts, CAFs) 的共培养体系. 方法· 采用不同类型胶原酶(Ⅰ 型, Ⅲ 型, Ⅳ 型) 处理5 …