Arterial hypertension is the most important contributor to the global burden of disease;
however, disease control remains poor. Although the diagnosis of hypertension is still based …

Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …

Background Blood pressure lowering is an established strategy for preventing microvascular
and macrovascular complications of diabetes, but its role in the prevention of diabetes itself …

The known genetic architecture of blood pressure now comprises> 30 genes, with rare
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …

Genome-wide association studies (GWAS) have identified thousands of genomic regions
affecting complex diseases. The next challenge is to elucidate the causal genes and …

Observational studies suggested a bidirectional correlation between depression and
metabolic syndrome (MetS) and its components. However, the causal associations between …

Context Iron overload is a known risk factor for type 2 diabetes (T2D); however, iron
overload and iron deficiency have both been associated with metabolic disorders in …

Genome-wide association studies on human behavioural traits are producing large amounts
of polygenic signals with significant predictive power and potentially useful biological clues …

Daytime napping is a common, heritable behavior, but its genetic basis and causal
relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide …

Although genetic risk scores have been used to predict hypertension, their utility in the
clinical setting remains uncertain. Our study comprised N= 218 792 FinnGen participants …