Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Objectives We review the evidence for tranexamic acid (TXA) for the treatment and
prevention of bleeding caused by surgery, trauma and bleeding disorders. We highlight …

Objective: To address the clinical and regulatory challenges of optimal primary endpoints for
bleeding patients by developing consensus-based recommendations for primary clinical …

Almost all bio-statisticians and medical researchers believe that a large sample is always
helpful in providing more reliable results. Whereas this is true for some specific cases, a …

Recent studies have demonstrated that only 30% of patients referred for assessment of a
possible bleeding tendency will eventually be diagnosed with a mild bleeding disorder …

Background Open pelvic fractures remain challenging in terms of their management. The
purpose of this narrative review was to evaluate the latest advances made in the …

Background Acute gastrointestinal bleeding is a common life-threatening emergent
condition. Immediate tranexamic acid is useful for reducing hemorrhage following operation …

This article discusses the importance and effectiveness of viscoelastic hemostatic assays
(VHAs) in assessing hemostatic competence and guiding blood component therapy (BCT) in …

There has been renewed interest in the use of low titer group O whole blood (LTOWB) for
the resuscitation of civilian casualties. LTOWB offers several advantages over conventional …

Placenta accreta spectrum (PAS) is a leading contributor to major obstetric hemorrhage and
severe maternal morbidity in the developed world. In the United States, PAS has become the …