Viral pathogen-induced mechanisms to antagonize mammalian interferon (IFN) signaling pathway
Antiviral responses of interferons (IFNs) are crucial in the host immune response, playing a
relevant role in controlling viralw infections. Three types of IFNs, type I (IFN-α, IFN-β), II (IFN …
relevant role in controlling viralw infections. Three types of IFNs, type I (IFN-α, IFN-β), II (IFN …
Evasion of I interferon-mediated innate immunity by pseudorabies virus
R Zhang, J Tang - Frontiers in microbiology, 2021 - frontiersin.org
Type I interferon (IFN-I) mediated innate immunity serves as the first line of host defense
against viral infection, ranging from IFN-I production upon viral detection, IFN-I triggered …
against viral infection, ranging from IFN-I production upon viral detection, IFN-I triggered …
Pseudorabies virus US3 protein inhibits IFN-β production by interacting with IRF3 to block its activation
J Xie, X Zhang, L Chen, Y Bi, A Idris, S Xu, X Li… - Frontiers in …, 2021 - frontiersin.org
Pseudorabies virus is a typical swine alphaherpesvirus, which can cause obvious
neurological disorders and reproductive failure in pigs. It is capable of evading host antiviral …
neurological disorders and reproductive failure in pigs. It is capable of evading host antiviral …
Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa
CJ Rodriguez-Hernandez… - Proceedings of the …, 2021 - National Acad Sciences
Here, we show that Porphyromonas gingivalis (Pg), an endogenous oral pathogen,
dampens all aspects of interferon (IFN) signaling in a manner that is strikingly similar to IFN …
dampens all aspects of interferon (IFN) signaling in a manner that is strikingly similar to IFN …
Conserved gammaherpesvirus protein kinase counters the antiviral effects of myeloid cell-specific STAT1 expression to promote the establishment of splenic B cell …
PA Sylvester, CN Jondle, KP Stoltz, J Lanham… - Journal of …, 2021 - Am Soc Microbiol
Gammaherpesviruses establish lifelong infections and are associated with B cell
lymphomas. Murine gammaherpesvirus 68 (MHV68) infects epithelial and myeloid cells …
lymphomas. Murine gammaherpesvirus 68 (MHV68) infects epithelial and myeloid cells …
T Cell-Intrinsic Interferon Regulatory Factor 1 Expression Suppresses Differentiation of CD4+ T Cell Populations That Support Chronic Gammaherpesvirus Infection
CN Jondle, KE Johnson, WP Mboko… - Journal of …, 2021 - Am Soc Microbiol
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection and are
associated with B cell lymphomas. To establish chronic infection, these viruses usurp B cell …
associated with B cell lymphomas. To establish chronic infection, these viruses usurp B cell …
Interferon Regulatory Factor 3 Supports the Establishment of Chronic Gammaherpesvirus Infection in a Route-and Dose-Dependent Manner
KE Johnson, PA Sylvester, CN Jondle… - Journal of …, 2021 - Am Soc Microbiol
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infections and are
associated with several malignancies, including B cell lymphomas. Uniquely, these viruses …
associated with several malignancies, including B cell lymphomas. Uniquely, these viruses …
[HTML][HTML] DEAD/DEAH-box helicase 5 is hijacked by an avian oncogenic herpesvirus to inhibit interferon beta production and promote viral replication
J Xu, Y Cai, Z Ma, B Jiang, W Liu, J Cheng… - Developmental & …, 2021 - Elsevier
Abstract DEAD-box helicase 5 (DDX5) plays a significant role in tumorigenesis and
regulates viral replication of several viruses. An avian oncogenic herpesvirus, Marek's …
regulates viral replication of several viruses. An avian oncogenic herpesvirus, Marek's …
[HTML][HTML] Two nuclear localization signals regulate intracellular localization of the duck enteritis virus UL13 protein
L Yang, X Hu, A Cheng, M Wang, R Jia, Q Yang, Y Wu… - Poultry science, 2021 - Elsevier
Duck enteritis virus (DEV) multifunctional tegument protein UL13 is predicted to be a
conserved herpesvirus protein kinase; however, little is known about its subcellular …
conserved herpesvirus protein kinase; however, little is known about its subcellular …
Zellzykluskontrolle β-herpesviraler Kinasen
M Schmidt - 2021 - refubium.fu-berlin.de
Herpesviren sind Meister der Koevolution, welche vielfach Gene und Sequenzmotive ihres
Wirtes entlehnen oder nachahmen, um zielgerichtet und effizient in zelluläre Prozesse …
Wirtes entlehnen oder nachahmen, um zielgerichtet und effizient in zelluläre Prozesse …