Artificial intelligence and machine learning techniques are breaking into biomedical
research and health care, which importantly includes cancer research and oncology, where …

Epigenetics studies inheritable and reversible modifications of DNA that allow cells to
control gene expression throughout their development and in response to environmental …

The transcription factor IRF8 is essential for the development of monocytes and dendritic
cells (DCs), whereas it inhibits neutrophilic differentiation. It is unclear how Irf8 expression is …

Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma
(PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular …

Enhancers are cis-regulatory elements containing short DNA sequences that serve as
binding sites for pioneer/regulatory transcription factors, thus orchestrating the regulation of …

Abstract The Epithelial-to-Mesenchymal Transition (EMT) is a developmental cellular
program frequently coopted by cancer cells and is a key contributor to both heterogeneity in …

Lineage commitment and differentiation is driven by the concerted action of master
transcriptional regulators at their target chromatin sites. Multiple efforts have characterized …

Understanding how epigenetic variation in non-coding regions is involved in distal gene-
expression regulation is an important problem. Regulatory regions can be associated to …

Enhancers control dynamic changes in gene expression and orchestrate the tightly
controlled transcriptional circuitries that direct and coordinate cell growth, proliferation …

We investigated tumor-cell-intrinsic chromatin accessibility patterns of pancreatic ductal
adenocarcinoma (PDAC) by ATAC-seq on EpCAM+ PDAC malignant epithelial cells, sorted …