Progress and challenges in virus genomic epidemiology

V Hill, C Ruis, S Bajaj, OG Pybus, MUG Kraemer - Trends in Parasitology, 2021 - cell.com
Genomic epidemiology, which links pathogen genomes with associated metadata to
understand disease transmission, has become a key component of outbreak response …

Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity

C Riou, R Keeton, T Moyo-Gwete… - Science translational …, 2021 - science.org
SARS-CoV-2 variants that escape neutralization and potentially affect vaccine efficacy have
emerged. T cell responses play a role in protection from reinfection and severe disease, but …

Coronavirus disease (COVID-19) control between drug repurposing and vaccination: a comprehensive overview

AA Al-Karmalawy, R Soltane, A Abo Elmaaty… - Vaccines, 2021 - mdpi.com
Respiratory viruses represent a major public health concern, as they are highly mutated,
resulting in new strains emerging with high pathogenicity. Currently, the world is suffering …

COVID-19 transmission dynamics underlying epidemic waves in Kenya

SPC Brand, J Ojal, R Aziza, V Were, EA Okiro… - Science, 2021 - science.org
Policy decisions on COVID-19 interventions should be informed by a local, regional and
national understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Africa: tackle HIV and COVID-19 together

N Msomi, R Lessells, K Mlisana, T de Oliveira - Nature, 2021 - nature.com
Africa: tackle HIV and COVID-19 together Skip to main content Thank you for visiting nature.com.
You are using a browser version with limited support for CSS. To obtain the best experience …

SARS-CoV-2 exposure in Malawian blood donors: an analysis of seroprevalence and variant dynamics between January 2020 and July 2021

J Mandolo, J Msefula, MYR Henrion, C Brown, B Moyo… - BMC medicine, 2021 - Springer
Abstract Background By August 2021, the COVID-19 pandemic has been less severe in sub-
Saharan Africa than elsewhere. In Malawi, there have been three subsequent epidemic …

Rapid replacement of the Beta variant by the Delta variant in South Africa

H Tegally, E Wilkinson, CL Althaus, M Giovanetti… - MedRxiv, 2021 - medrxiv.org
The Beta variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
emerged in South Africa in late 2020 and rapidly became the dominant variant, causing over …

Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A. 23.1 identified in …

B Lubinski, LE Frazier, MVT Phan, DL Bugembe… - bioRxiv, 2021 - biorxiv.org
The African continent like all other parts of the world with high infection/low vaccination rates
can, and will, be a source of novel SARS-CoV-2 variants. The A. 23 viral lineage …

Cross-reactive antibodies to SARS-CoV-2 and MERS-CoV in pre-COVID-19 blood samples from Sierra Leoneans

R Borrega, DKS Nelson, AP Koval, NG Bond… - Viruses, 2021 - mdpi.com
Many countries in sub-Saharan Africa have experienced lower COVID-19 caseloads and
fewer deaths than countries in other regions worldwide. Under-reporting of cases and a …

Emergence and phenotypic characterization of C. 1.2, a globally detected lineage that rapidly accumulated mutations of concern

C Scheepers, J Everatt, DG Amoako, H Tegally… - MedRxiv, 2021 - medrxiv.org
SARS-CoV-2 variants of interest have been associated with increased transmissibility,
neutralization resistance and disease severity. Ongoing SARS-CoV-2 genomic surveillance …