Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through
the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion …

Cardiac fibrosis, a common pathophysiologic process in most heart diseases, refers to an
excess of extracellular matrix (ECM) deposition by cardiac fibroblasts (CFs), which can lead …

Passive mechanical tissue properties are major determinants of myocardial contraction and
relaxation and, thus, shape cardiac function. Tightly regulated, dynamically adapting …

Cardiac fibrosis is a common finding that is associated with the progression of heart failure
(HF) and impacts all chambers of the heart. Despite intense research, the treatment of HF …

Heart failure (HF) is a leading cause of morbidity and mortality across the world. Cardiac
fibrosis is associated with HF progression. Fibrosis is characterized by the excessive …

Background: Myocardial infarction (MI) induces an intense injury response that ultimately
generates a collagen-dominated scar. Although required to prevent ventricular rupture, the …

Conclusions The CF has recently emerged as one of the most phenotypically plastic cells in
the heart, with distinct transcriptional and secretory programs that regulate their essential …

Heart failure threatens the lives of patients and reduces their quality of life. Heart failure,
especially heart failure with preserved ejection fraction, is closely related to systemic and …

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder,
affecting 1 in 500 people in the general population. Although characterized by asymmetric …

Tissue repair and fibrosis, an abnormal form of repair, occur in most human organs in
response to injury or inflammation. Fibroblasts play a major role in the normal repair process …