Improving the survival of patients with osteosarcoma has long proved challenging, although
the treatment of this disease is on the precipice of advancement. The increasing feasibility of …

Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

Osteosarcoma is one of the most prevalent primary bone tumors with a high metastatic and
recurrence rate with poor prognosis. MiRNAs are short and non-coding RNAs that could …

Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the
clonal interactive network involved in this process remains unclear. Here, we optimized the …

Background: The tumor microenvironment (TME) mainly comprises tumor cells and tumor-
infiltrating immune cells mixed with stromal components. Latestresearch hasdisplayed that …

Simple Summary Osteosarcoma (OS) is the most common bone tumor in the pediatric
population, and long-term survival occurs in less than a third of the population with …

MicroRNAs (miRNAs) are approximately 20–22 nucleotides in length, which are well known
to participate in the post-transcriptional modification. The mature miRNAs were observed to …

Transmembrane protein 206 (TMEM206), a proton‐activated chloride channel, has been
implicated in various biochemical processes, including bone metabolism, and has emerged …

A patient's tumor cells are heterogeneous with differing phenotypic adaptations that facilitate
selection in response to changing environmental conditions. This intra-tumor heterogeneity …

Canine osteosarcoma is a form of malignant bone tumor most common in large and giant
dog breeds such as Rottweilers, Saint Bernards, Irish Wolfhounds or Great Danes, often …