[HTML][HTML] Plasma membrane integrity: implications for health and disease
DA Ammendolia, WM Bement, JH Brumell - BMC biology, 2021 - Springer
Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience
plasma membrane damage from a multitude of stressors in the extra-and intra-cellular …
plasma membrane damage from a multitude of stressors in the extra-and intra-cellular …
[HTML][HTML] Protein profile of fiber types in human skeletal muscle: a single-fiber proteomics study
Background Human skeletal muscle is composed of three major fiber types, referred to as
type 1, 2A, and 2X fibers. This heterogeneous cellular composition complicates the …
type 1, 2A, and 2X fibers. This heterogeneous cellular composition complicates the …
[HTML][HTML] MG53, a tissue repair protein with broad applications in regenerative medicine
Z Li, L Wang, H Yue, BA Whitson, E Haggard, X Xu… - Cells, 2021 - mdpi.com
Under natural conditions, injured cells can be repaired rapidly through inherent biological
processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy …
processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy …
[HTML][HTML] MG53 suppresses NF-κB activation to mitigate age-related heart failure
Aging is associated with chronic oxidative stress and inflammation that affect tissue repair
and regeneration capacity. MG53 is a TRIM family protein that facilitates repair of cell …
and regeneration capacity. MG53 is a TRIM family protein that facilitates repair of cell …
[HTML][HTML] Muscle proteomic and transcriptomic profiling of healthy aging and metabolic syndrome in men
M Gueugneau, C Coudy-Gandilhon… - International Journal of …, 2021 - mdpi.com
(1) Background: Aging is associated with a progressive decline in muscle mass and
function. Aging is also a primary risk factor for metabolic syndrome, which further alters …
function. Aging is also a primary risk factor for metabolic syndrome, which further alters …
Proteomic analysis identifies key differences in the cardiac interactomes of dystrophin and micro-dystrophin
H Wang, E Marrosu, D Brayson… - Human Molecular …, 2021 - academic.oup.com
Abstract ΔR4-R23/ΔCT micro-dystrophin (μDys) is a miniaturized version of dystrophin
currently evaluated in a Duchenne muscular dystrophy (DMD) gene therapy trial to treat …
currently evaluated in a Duchenne muscular dystrophy (DMD) gene therapy trial to treat …
Sarcolemma wounding activates dynamin‐dependent endocytosis in striated muscle
JR McDade, MT Naylor, DE Michele - The FEBS journal, 2021 - Wiley Online Library
Plasma membrane repair is an evolutionarily conserved mechanism by which cells can seal
breaches in the plasma membrane. Mutations in several proteins with putative roles in …
breaches in the plasma membrane. Mutations in several proteins with putative roles in …
Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration
Through stress and injury to tissues, the cell membrane is damaged and can lead to cell
death and a cascade of inflammatory events. Soluble factors that mitigate and repair …
death and a cascade of inflammatory events. Soluble factors that mitigate and repair …
[HTML][HTML] MG53 preserves neuromuscular junction integrity and alleviates ALS disease progression
Respiratory failure from progressive respiratory muscle weakness is the most common
cause of death in amyotrophic lateral sclerosis (ALS). Defects in neuromuscular junctions …
cause of death in amyotrophic lateral sclerosis (ALS). Defects in neuromuscular junctions …
Recombinant Human MG53 Protein Protects Against Alkaline-Induced Corneal Injuries in Mice
O Guo, B Ju, MKH Shawver, B Geng, S Wei… - Military …, 2021 - academic.oup.com
Introduction The current study was designed to test the potential role of recombinant human
MG53 (rhMG53) protein on protecting against alkaline-induced corneal injury in mice …
MG53 (rhMG53) protein on protecting against alkaline-induced corneal injury in mice …