Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience
plasma membrane damage from a multitude of stressors in the extra-and intra-cellular …

Background Human skeletal muscle is composed of three major fiber types, referred to as
type 1, 2A, and 2X fibers. This heterogeneous cellular composition complicates the …

Under natural conditions, injured cells can be repaired rapidly through inherent biological
processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy …

Aging is associated with chronic oxidative stress and inflammation that affect tissue repair
and regeneration capacity. MG53 is a TRIM family protein that facilitates repair of cell …

(1) Background: Aging is associated with a progressive decline in muscle mass and
function. Aging is also a primary risk factor for metabolic syndrome, which further alters …

Abstract ΔR4-R23/ΔCT micro-dystrophin (μDys) is a miniaturized version of dystrophin
currently evaluated in a Duchenne muscular dystrophy (DMD) gene therapy trial to treat …

Plasma membrane repair is an evolutionarily conserved mechanism by which cells can seal
breaches in the plasma membrane. Mutations in several proteins with putative roles in …

Through stress and injury to tissues, the cell membrane is damaged and can lead to cell
death and a cascade of inflammatory events. Soluble factors that mitigate and repair …

Respiratory failure from progressive respiratory muscle weakness is the most common
cause of death in amyotrophic lateral sclerosis (ALS). Defects in neuromuscular junctions …

Introduction The current study was designed to test the potential role of recombinant human
MG53 (rhMG53) protein on protecting against alkaline-induced corneal injury in mice …