Ischemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to
the brain. Ischemia would initiate the cascade reaction consisted of multiple biochemical …

Nerve growth factor (NGF) was the first-discovered member of the neurotrophin family, a
class of bioactive molecules which exerts powerful biological effects on the CNS and other …

The blood–brain barrier (BBB) is composed of brain endothelial cells, pericytes, and
astrocytes, which build a tight cellular barrier. Therapeutic (macro) molecules are not able to …

Targeted delivery of doxorubicin still poses a challenge with regards to the quantities
reaching the target site as well as the specificity of the uptake. In the present approach, two …

A growing number of nanomedicines entered the clinical trials and improved our
understanding of the in vivo responses expected in humans. The in vitro drug release …

The ischemia and hypoxia microenvironment after spinal cord injury (SCI) makes SCI repair
a challenging problem. With various stimulus, chances for neural stem cells (NSCs) to …

Nanoparticulate drug delivery systems provide a vast number of potential nanomedicines.
Biocompatible synthetic and natural polymers are especially promising materials for …

Introduction: Cerebrovascular diseases encompass various disorders of the brain
vasculature, such as ischemic/hemorrhagic strokes, aneurysms, and vascular …

Some metal ions of the d-block are necessary for the proper growth, functioning and
maintenance of the central nervous system. In particular, copper and zinc ions have …

Stroke is a group of major diseases that cause death or disability in adults, with high
incidence and lack of available therapeutic strategies. Although traditional Chinese …