Parkinson's disease is an increasingly prevalent and currently incurable neurodegenerative
disorder. At the molecular level, this disease is characterized by the formation of aberrant …

Many neurodegenerative diseases are rooted in the activities of amyloid-like proteins which
possess conformations that spread to healthy proteins. These include Alzheimer's disease …

Interfaces can strongly accelerate or inhibit protein aggregation, destabilizing proteins that
are stable in solution or, conversely, stabilizing proteins that are aggregation-prone …

The prediction of highly ordered three-dimensional structures of amyloid protein fibrils from
the amino acid sequences of their monomeric self-assembly precursors constitutes a …

The aberrant aggregation of proteins is a key molecular event in the development and
progression of a wide range of neurodegenerative disorders. We have shown previously …

An interruption in Aβ homeostasis leads to the deposit of neurotoxic amyloid plaques and is
associated with Alzheimer's disease. A supramolecular strategy based on the assembly of …

Protein aggregation phenomenon is closely related to the formation of amyloids which
results in many neurodegenerative diseases like Alzheimer's, Parkinson's, Huntington's, and …

Molecular chaperones are key components of the cellular proteostasis network whose role
includes the suppression of the formation and proliferation of pathogenic aggregates …

Several cell-surface receptors for neurotoxic forms of amyloid-β (Aβ) have been described,
but their molecular interactions with Aβ assemblies and their relative contributions to …

The abnormal deposition of fibrillar beta-amyloid (Aβ) deposits in the brain is one of the
major histopathological hallmarks of Alzheimer's disease (AD). Here, we characterized …