QbD-steered development of biotin-conjugated nanostructured lipid carriers for oral delivery of chrysin: role of surface modification for improving biopharmaceutical …

T Sharma, OP Katare, A Jain, S Jain… - Colloids and Surfaces B …, 2021 - Elsevier
Bioactives are documented to exhibit diverse pharmacological activities, however, their low
and inconsistent bioavailability primarily pose serious impediment against their potential …

An HPTLC densitometric method for simultaneous quantification of sorafenib tosylate and chrysin: Analytical method development, validation and applications

T Sharma, RK Khurana, B Borges, R Kaur… - Microchemical …, 2021 - Elsevier
Since decades, the plant bioactives have shown tremendous promise in the therapeutic
management of cancer. Lately, many synthetic drugs and natural bioactive molecules have …

Galactosylated nanoconstructs of Berberine with enhanced Biopharmaceutical and cognitive potential: A preclinical evidence in Alzheimer's disease

S Lohan, T Sharma, S Saini, A Singh, A Kumar… - Journal of Drug Delivery …, 2021 - Elsevier
Numerous oral treatment options have been reported for neurological diseases, particularly
Alzheimer's disease (AD). Berberine (BRB), a promising phytoactive drug, has been …

[PDF][PDF] Novel Methotrexate-Loaded Zein Nanoparticles With Improved and Extended Biopharmaceutical Performance: QbD-Steered Development, and Extensive In …

A Jain, T Sharma, R Kumar, S Saini, J Kaur, OP Katare… - 2021 - academia.edu
The current work entails QbD-enabled preparation of methotrexate-loaded nanoparticles
(NPs) using zein as the releasecontrolling natural polymer. Initially, quality risk …