COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects

DM Smadja, SJ Mentzer, M Fontenay, MA Laffan… - Angiogenesis, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …

Pathophysiology of acute respiratory distress syndrome and COVID-19 lung injury

KE Swenson, ER Swenson - Critical care clinics, 2021 - criticalcare.theclinics.com
Acute respiratory distress syndrome (ARDS) is a complex syndrome of acute lung injury
leading to noncardiogenic pulmonary edema from many causes that is heterogenous in its …

Mechanical ventilation parameters in critically ill COVID-19 patients: a scoping review

G Grasselli, E Cattaneo, G Florio, M Ippolito, A Zanella… - Critical Care, 2021 - Springer
Background The mortality of critically ill patients with COVID-19 is high, particularly among
those receiving mechanical ventilation (MV). Despite the high number of patients treated …

Intensive care management of patients with COVID-19: a practical approach

LA Hajjar, IBSS Costa, SI Rizk, B Biselli… - Annals of Intensive …, 2021 - Springer
Abstract SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is
responsible for the largest pandemic facing humanity since the Spanish flu pandemic in the …

Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality

A Philippe, R Chocron, N Gendron, O Bory, A Beauvais… - Angiogenesis, 2021 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is a respiratory disease
associated with endotheliitis and microthrombosis. Objectives To correlate endothelial …

Platelet activation in critically ill COVID-19 patients

N Yatim, J Boussier, R Chocron, J Hadjadj… - Annals of intensive …, 2021 - Springer
Background Microvascular, arterial and venous thrombotic events have been largely
described during severe coronavirus disease 19 (COVID-19). However, mechanisms …

Computed tomography assessment of PEEP-induced alveolar recruitment in patients with severe COVID-19 pneumonia

L Ball, C Robba, L Maiello, J Herrmann, SE Gerard… - Critical Care, 2021 - Springer
Background There is a paucity of data concerning the optimal ventilator management in
patients with COVID-19 pneumonia; particularly, the optimal levels of positive-end expiratory …

Endothelialitis plays a central role in the pathophysiology of severe COVID-19 and its cardiovascular complications

CJM Vrints, KA Krychtiuk… - Acta …, 2021 - Taylor & Francis
This clinical review paper discusses the pathophysiology of the pulmonary and
cardiovascular manifestations of a SARS-CoV-2 infection and the ensuing implications on …

Prevalence and characteristics of pulmonary embolism in 1042 COVID-19 patients with respiratory symptoms: A nested case-control study

B Planquette, A Le Berre, L Khider, A Yannoutsos… - Thrombosis …, 2021 - Elsevier
Abstract Introduction Coronavirus disease 2019 (COVID-19) has been associated with
cardiovascular complications and coagulation disorders. Previous studies reported …

Anticoagulation before hospitalization is a potential protective factor for COVID‐19: insight from a French multicenter cohort study

R Chocron, V Galand, J Cellier, N Gendron… - Journal of the …, 2021 - Am Heart Assoc
Background Coronavirus disease 2019 (COVID‐19) is a respiratory disease associated with
thrombotic outcomes with coagulation and endothelial disorders. Based on that, several …