Abstract Modern nosologies (eg, International Classification of Diseases, 11th edition [ICD-
11], Diagnostic and Statistical Manual of Mental Disorders, 5th edition [DSM–5]) for alcohol …

Addiction is a disease characterized by compulsive drug seeking and consumption
observed in 20–30% of users. An addicted individual will favor drug reward over natural …

Alcohol intake remains controlled in a majority of users but becomes “compulsive,” ie,
continues despite adverse consequences, in a minority who develop alcohol addiction …

Recurring episodes of excessive food intake in binge eating disorder can be understood
through the lens of behavioral control systems: patients repeat maladaptive behaviors …

The heightened incidence of opioid use during pregnancy has resulted in unprecedented
rates of neonates prenatally exposed to opioids. Prenatal opioid exposure (POE) results in …

Rationale In classical conditioning, sign-tracking reflects behavior directed toward a
conditioned stimulus (CS) in expectation of a reward (unconditioned stimulus, US); in …

Cognitive deficits are highly comorbid with substance use disorders. Deficits span multiple
cognitive domains, are associated with disease severity across substance classes, and …

Drugs of abuse, including alcohol and stimulants like cocaine, produce effects that are
subject to individual variability, and genetic variation accounts for at least a portion of those …

The transition from controlled drug use to drug addiction depends on an interaction between
a vulnerable individual, their environment and a drug. Here we tested the hypothesis that …

While most individuals with access to alcohol drink it recreationally, some vulnerable
individuals eventually lose control over their intake and progressively develop compulsive …