The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection
Q Le Hingrat, I Sereti, AL Landay, I Pandrea… - Frontiers in …, 2021 - frontiersin.org
CD4+ T-cell depletion is pathognomonic for AIDS in both HIV and simian immunodeficiency
virus (SIV) infections. It occurs early, is massive at mucosal sites, and is not entirely reverted …
virus (SIV) infections. It occurs early, is massive at mucosal sites, and is not entirely reverted …
The interplay of HIV and autophagy in early infection
R Cabrera-Rodríguez, S Pérez-Yanes… - Frontiers in …, 2021 - frontiersin.org
HIV/AIDS is still a global threat despite the notable efforts made by the scientific and health
communities to understand viral infection, to design new drugs or to improve existing ones …
communities to understand viral infection, to design new drugs or to improve existing ones …
Sec24C is an HIV-1 host dependency factor crucial for virus replication
Early events of the human immunodeficiency virus 1 (HIV-1) lifecycle, such as post-entry
virus trafficking, uncoating and nuclear import, are poorly characterized because of limited …
virus trafficking, uncoating and nuclear import, are poorly characterized because of limited …
HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave
There are conflicting reports on the effects of HIV on COVID-19. Here, we analyzed disease
severity and immune cell changes during and after SARS-CoV-2 infection in 236 …
severity and immune cell changes during and after SARS-CoV-2 infection in 236 …
Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2
The current health crisis of corona virus disease 2019 (COVID-19) highlights the urgent
need for vaccine systems that can generate potent and protective immune responses …
need for vaccine systems that can generate potent and protective immune responses …
Optimizing pharmacology studies in pregnant and lactating women using lessons from HIV: a consensus statement
AC Eke, A Olagunju, J Momper… - Clinical …, 2021 - Wiley Online Library
Information on the extent of drug exposure to mothers and infants during pregnancy and
lactation normally becomes available years after regulatory approval of a drug. Clinicians …
lactation normally becomes available years after regulatory approval of a drug. Clinicians …
Dual pathways of human immunodeficiency virus type 1 envelope glycoprotein trafficking modulate the selective exclusion of uncleaved oligomers from virions
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer is
transported through the secretory pathway to the infected cell surface and onto virion …
transported through the secretory pathway to the infected cell surface and onto virion …
Structure, Synthesis and Inhibition Mechanism of Nucleoside Analogues as HIV‐1 Reverse Transcriptase Inhibitors (NRTIs)
Y Yoshida, M Honma, Y Kimura, H Abe - ChemMedChem, 2021 - Wiley Online Library
Acquired immunodeficiency syndrome (AIDS) is caused by infection with the human
immunodeficiency virus (HIV). Although treatments against HIV infection are available, AIDS …
immunodeficiency virus (HIV). Although treatments against HIV infection are available, AIDS …
Asymmetric structures and conformational plasticity of the uncleaved full-length human immunodeficiency virus envelope glycoprotein trimer
The functional human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer
[(gp120/gp41) 3] is produced by cleavage of a conformationally flexible gp160 precursor …
[(gp120/gp41) 3] is produced by cleavage of a conformationally flexible gp160 precursor …
Optimisation of a TALE nuclease targeting the HIV co-receptor CCR5 for clinical application
LI Schwarze, D Głów, T Sonntag, A Uhde, B Fehse - Gene Therapy, 2021 - nature.com
Disruption of the CC-Chemokine-receptor-5 (CCR5) gene induces resistance towards
CCR5-tropic HIV. Here we optimised our previously described CCR5-Uco-TALEN and its …
CCR5-tropic HIV. Here we optimised our previously described CCR5-Uco-TALEN and its …