[HTML][HTML] The neurovascular unit dysfunction in Alzheimer's disease
LO Soto-Rojas, M Pacheco-Herrero… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide.
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and …
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and …
Alzheimer's disease: related targets, synthesis of available drugs, bioactive compounds under development and promising results obtained from multi-target …
NFF Pirolla, VS Batista, FP Dias Viegas… - Current Drug …, 2021 - ingentaconnect.com
We describe herein the therapeutic targets involved in Alzheimer's disease as well as the
available drugs and their synthetic routes. Bioactive compounds under development are …
available drugs and their synthetic routes. Bioactive compounds under development are …
[HTML][HTML] Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology
MR Tropea, DDL Puma, M Melone, W Gulisano… - Progress in …, 2021 - Elsevier
The accumulation of amyloid-beta peptide (Aβ) and the failure of cholinergic transmission
are key players in Alzheimer's disease (AD). However, in the healthy brain, Aβ contributes to …
are key players in Alzheimer's disease (AD). However, in the healthy brain, Aβ contributes to …
Effect of aluminum combined with ApoEε4 on Tau phosphorylation and Aβ deposition
Y Wang, H Li, J Zhang, Y Han, J Song, L Wang… - Journal of Trace …, 2021 - Elsevier
Background Aluminum is an environmental neurotoxin widely exposed to animals and
humans. Studies have shown that Alzheimer's disease (AD) is characterized by abnormally …
humans. Studies have shown that Alzheimer's disease (AD) is characterized by abnormally …
[HTML][HTML] Apigenin and structurally related flavonoids allosterically potentiate the function of human α7-nicotinic acetylcholine receptors expressed in SH-EP1 cells
Phytochemicals, such as monoterpenes, polyphenols, curcuminoids, and flavonoids, are
known to have anti-inflammatory, antioxidant, neuroprotective, and procognitive effects. In …
known to have anti-inflammatory, antioxidant, neuroprotective, and procognitive effects. In …
Uma molécula racionalmente desenvolvida eficaz em modelos animais de demência e com associação à transtornos psiquiátricos
MG Fronza - 2021 - repositorio.ufpel.edu.br
Resumo FRONZA, Mariana G. QTC-4-MeOBnA: Uma molécula racionalmente desenvolvida
eficaz em modelos animais de demência e com associação à transtornos psiquiátricos …
eficaz em modelos animais de demência e com associação à transtornos psiquiátricos …
Retinal Regeneration in a Genetic Mouse Model of Glaucoma
J Paris - 2021 - scholarworks.wmich.edu
Glaucoma is a degenerative retinal disease characterized by progressive loss of retinal
ganglion cells (RGCs). Previous studies have shown that application of a specific α7 …
ganglion cells (RGCs). Previous studies have shown that application of a specific α7 …
A failure of β-amyloid physiological function due to genetic deletion of α7 nicotinic acetylcholine receptors induces an Alzheimer's disease-like pathology
MR Tropea, DDL Puma, M Melone, W Gulisano… - bioRxiv, 2021 - biorxiv.org
The accumulation of amyloid-beta peptide (Aβ) and the failure of cholinergic transmission
are key players in Alzheimer's disease (AD). However, in the healthy brain, Aβ contributes to …
are key players in Alzheimer's disease (AD). However, in the healthy brain, Aβ contributes to …