Ceramides in metabolism: key lipotoxic players
B Chaurasia, SA Summers - Annual review of physiology, 2021 - annualreviews.org
The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
The lifecycle of skeletal muscle mitochondria in obesity
CA Pileggi, G Parmar, ME Harper - Obesity Reviews, 2021 - Wiley Online Library
Skeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …
[HTML][HTML] High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain …
Mitochondrial defects are implicated in multiple diseases and aging. Exercise training is an
accessible, inexpensive therapeutic intervention that can improve mitochondrial …
accessible, inexpensive therapeutic intervention that can improve mitochondrial …
Incorporating fatty liver disease in multidisciplinary care and novel clinical trial designs for patients with metabolic diseases
With the global epidemics of obesity and associated conditions, including type 2 diabetes,
metabolic dysfunction-associated fatty liver disease, chronic kidney disease, hypertension …
metabolic dysfunction-associated fatty liver disease, chronic kidney disease, hypertension …
Cholesterol–the devil you know; ceramide–the devil you don't
TS Tippetts, WL Holland, SA Summers - Trends in pharmacological …, 2021 - cell.com
Ectopic lipids play a key role in numerous pathologies, including heart disease, stroke, and
diabetes. Of all the lipids studied, perhaps the most well understood is cholesterol, a widely …
diabetes. Of all the lipids studied, perhaps the most well understood is cholesterol, a widely …
[HTML][HTML] Circulating ceramides as biomarkers of cardiovascular disease: Evidence from phenotypic and genomic studies
KA McGurk, BD Keavney, A Nicolaou - Atherosclerosis, 2021 - Elsevier
There is a need for new biomarkers of atherosclerotic cardiovascular disease (ACVD), the
main cause of death globally. Ceramides, a class of potent bioactive lipid mediators, have …
main cause of death globally. Ceramides, a class of potent bioactive lipid mediators, have …
[HTML][HTML] Plasma ceramides pathophysiology, measurements, challenges, and opportunities
M Gaggini, A Pingitore, C Vassalle - Metabolites, 2021 - mdpi.com
Ceramides are a family of lipid molecules, composed of sphingosine and a fatty acid, and
transported by lipoproteins (primarily by low-density lipoproteins) in the bloodstream. They …
transported by lipoproteins (primarily by low-density lipoproteins) in the bloodstream. They …
[HTML][HTML] Peak week recommendations for bodybuilders: An evidence based approach
G Escalante, SW Stevenson, C Barakat… - BMC Sports Science …, 2021 - Springer
Bodybuilding is a competitive endeavor where a combination of muscle size, symmetry,“
conditioning”(low body fat levels), and stage presentation are judged. Success in …
conditioning”(low body fat levels), and stage presentation are judged. Success in …
[HTML][HTML] Systems biology approaches to study lipidomes in health and disease
Lipids have many important biological roles, such as energy storage sources, structural
components of plasma membranes and as intermediates in metabolic and signaling …
components of plasma membranes and as intermediates in metabolic and signaling …
Exercise-nutrient interactions for improved postprandial glycemic control and insulin sensitivity
JB Gillen, S Estafanos, A Govette - … Physiology, Nutrition, and …, 2021 - cdnsciencepub.com
Type 2 diabetes (T2D) is a rapidly growing yet largely preventable chronic disease.
Exaggerated increases in blood glucose concentration following meals is a primary …
Exaggerated increases in blood glucose concentration following meals is a primary …