Ceramides in metabolism: key lipotoxic players

B Chaurasia, SA Summers - Annual review of physiology, 2021 - annualreviews.org
The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

The lifecycle of skeletal muscle mitochondria in obesity

CA Pileggi, G Parmar, ME Harper - Obesity Reviews, 2021 - Wiley Online Library
Skeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …

[HTML][HTML] High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain …

C Granata, NJ Caruana, J Botella, NA Jamnick… - Nature …, 2021 - nature.com
Mitochondrial defects are implicated in multiple diseases and aging. Exercise training is an
accessible, inexpensive therapeutic intervention that can improve mitochondrial …

Incorporating fatty liver disease in multidisciplinary care and novel clinical trial designs for patients with metabolic diseases

M Eslam, A Ahmed, JP Després, V Jha… - The Lancet …, 2021 - thelancet.com
With the global epidemics of obesity and associated conditions, including type 2 diabetes,
metabolic dysfunction-associated fatty liver disease, chronic kidney disease, hypertension …

Cholesterol–the devil you know; ceramide–the devil you don't

TS Tippetts, WL Holland, SA Summers - Trends in pharmacological …, 2021 - cell.com
Ectopic lipids play a key role in numerous pathologies, including heart disease, stroke, and
diabetes. Of all the lipids studied, perhaps the most well understood is cholesterol, a widely …

[HTML][HTML] Circulating ceramides as biomarkers of cardiovascular disease: Evidence from phenotypic and genomic studies

KA McGurk, BD Keavney, A Nicolaou - Atherosclerosis, 2021 - Elsevier
There is a need for new biomarkers of atherosclerotic cardiovascular disease (ACVD), the
main cause of death globally. Ceramides, a class of potent bioactive lipid mediators, have …

[HTML][HTML] Plasma ceramides pathophysiology, measurements, challenges, and opportunities

M Gaggini, A Pingitore, C Vassalle - Metabolites, 2021 - mdpi.com
Ceramides are a family of lipid molecules, composed of sphingosine and a fatty acid, and
transported by lipoproteins (primarily by low-density lipoproteins) in the bloodstream. They …

[HTML][HTML] Peak week recommendations for bodybuilders: An evidence based approach

G Escalante, SW Stevenson, C Barakat… - BMC Sports Science …, 2021 - Springer
Bodybuilding is a competitive endeavor where a combination of muscle size, symmetry,“
conditioning”(low body fat levels), and stage presentation are judged. Success in …

[HTML][HTML] Systems biology approaches to study lipidomes in health and disease

MA Alves, S Lamichhane, A Dickens… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Lipids have many important biological roles, such as energy storage sources, structural
components of plasma membranes and as intermediates in metabolic and signaling …

Exercise-nutrient interactions for improved postprandial glycemic control and insulin sensitivity

JB Gillen, S Estafanos, A Govette - … Physiology, Nutrition, and …, 2021 - cdnsciencepub.com
Type 2 diabetes (T2D) is a rapidly growing yet largely preventable chronic disease.
Exaggerated increases in blood glucose concentration following meals is a primary …