[HTML][HTML] Targeting toll-like receptor (TLR) pathways in inflammatory arthritis: two better than one?
S Santos-Sierra - Biomolecules, 2021 - mdpi.com
Inflammatory arthritis is a cluster of diseases caused by unregulated activity of the immune
system. The lost homeostasis is followed by the immune attack of one's self, what damages …
system. The lost homeostasis is followed by the immune attack of one's self, what damages …
Serum amyloid A and inflammasome activation: A link to breast cancer progression?
Breast cancer is the most frequently diagnosed cancer in women globally. Although there
have been many significant advances made in the diagnosis and treatment of breast cancer …
have been many significant advances made in the diagnosis and treatment of breast cancer …
Biodegradable anti-ultraviolet film from modified gallic acid cross-linked gelatin
L Guo, T Qiang, Y Ma, L Ren, C Zhu - ACS Sustainable Chemistry …, 2021 - ACS Publications
The use of leather production waste to prepare degradable films is a sustainable production
concept that can improve resource utilization and reduce the environmental pollution …
concept that can improve resource utilization and reduce the environmental pollution …
Toll‐like receptor 2 activation and up‐regulation by high mobility group box‐1 contribute to post‐operative neuroinflammation and cognitive dysfunction in mice
F Lin, W Shan, Y Zheng, L Pan… - Journal of …, 2021 - Wiley Online Library
Post‐operative cognitive dysfunction (POCD) is common and is associated with poor clinical
outcome. Toll‐like receptor (TLR) 3 and 4 have been implied in the development of POCD …
outcome. Toll‐like receptor (TLR) 3 and 4 have been implied in the development of POCD …
Design, Synthesis, and Structure–Activity Relationship of N-Aryl-N′-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential …
Z Chen, L Zhang, J Yang, L Zheng, F Hu… - Journal of Medicinal …, 2021 - ACS Publications
The previous virtual screening of ten million compounds yielded two novel nonlipopeptide-
like chemotypes as TLR2 agonists. Herein, we present the chemical optimization of our …
like chemotypes as TLR2 agonists. Herein, we present the chemical optimization of our …
Proteomic landscape of Japanese encephalitis virus-infected fibroblasts
KB Sharma, S Chhabra, S Aggarwal… - Journal of General …, 2021 - microbiologyresearch.org
Advances in proteomics have enabled a comprehensive understanding of host–pathogen
interactions. Here we have characterized Japanese encephalitis virus (JEV) infection-driven …
interactions. Here we have characterized Japanese encephalitis virus (JEV) infection-driven …
[PDF][PDF] For whom the disc tolls: intervertebral disc degeneration, back pain and toll-like receptors
Intervertebral disc (IVD) degeneration is characterised by catabolic and inflammatory
processes that contribute largely to tissue degradation and chronic back pain. The disc cells …
processes that contribute largely to tissue degradation and chronic back pain. The disc cells …
[HTML][HTML] Peptidoglycan switches off the TLR2-mediated sperm recognition and triggers sperm localization in the bovine endometrium
In mammals, the uterine mucosal immune system simultaneously recognizes and reacts to
most bacteria as well as allogenic sperm mainly through the Toll-like receptors (TLR) 2/4 …
most bacteria as well as allogenic sperm mainly through the Toll-like receptors (TLR) 2/4 …
Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders
S Miller, MJ Blanco - RSC Medicinal Chemistry, 2021 - pubs.rsc.org
Chronically activated microglia and the resulting cascade of neuroinflammatory mechanisms
have been postulated to play a critical role in neurodegenerative disorders. Microglia are the …
have been postulated to play a critical role in neurodegenerative disorders. Microglia are the …
Role of atypical chemokines and chemokine receptors pathways in the pathogenesis of COPD
F Nucera, F Lo Bello, SS Shen… - Current medicinal …, 2021 - ingentaconnect.com
Chronic obstructive pulmonary disease (COPD) represents a heightened inflammatory
response in the lung generally resulting from tobacco smoking-induced recruitment and …
response in the lung generally resulting from tobacco smoking-induced recruitment and …