[HTML][HTML] Targeting toll-like receptor (TLR) pathways in inflammatory arthritis: two better than one?

S Santos-Sierra - Biomolecules, 2021 - mdpi.com
Inflammatory arthritis is a cluster of diseases caused by unregulated activity of the immune
system. The lost homeostasis is followed by the immune attack of one's self, what damages …

Serum amyloid A and inflammasome activation: A link to breast cancer progression?

C Fourie, P Shridas, T Davis, WJS de Villiers… - Cytokine & Growth …, 2021 - Elsevier
Breast cancer is the most frequently diagnosed cancer in women globally. Although there
have been many significant advances made in the diagnosis and treatment of breast cancer …

Biodegradable anti-ultraviolet film from modified gallic acid cross-linked gelatin

L Guo, T Qiang, Y Ma, L Ren, C Zhu - ACS Sustainable Chemistry …, 2021 - ACS Publications
The use of leather production waste to prepare degradable films is a sustainable production
concept that can improve resource utilization and reduce the environmental pollution …

Toll‐like receptor 2 activation and up‐regulation by high mobility group box‐1 contribute to post‐operative neuroinflammation and cognitive dysfunction in mice

F Lin, W Shan, Y Zheng, L Pan… - Journal of …, 2021 - Wiley Online Library
Post‐operative cognitive dysfunction (POCD) is common and is associated with poor clinical
outcome. Toll‐like receptor (TLR) 3 and 4 have been implied in the development of POCD …

Design, Synthesis, and Structure–Activity Relationship of N-Aryl-N′-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential …

Z Chen, L Zhang, J Yang, L Zheng, F Hu… - Journal of Medicinal …, 2021 - ACS Publications
The previous virtual screening of ten million compounds yielded two novel nonlipopeptide-
like chemotypes as TLR2 agonists. Herein, we present the chemical optimization of our …

Proteomic landscape of Japanese encephalitis virus-infected fibroblasts

KB Sharma, S Chhabra, S Aggarwal… - Journal of General …, 2021 - microbiologyresearch.org
Advances in proteomics have enabled a comprehensive understanding of host–pathogen
interactions. Here we have characterized Japanese encephalitis virus (JEV) infection-driven …

[PDF][PDF] For whom the disc tolls: intervertebral disc degeneration, back pain and toll-like receptors

DG Bisson, M Mannarino, R Racine, L Haglund - Eur Cell Mater, 2021 - ecmjournal.org
Intervertebral disc (IVD) degeneration is characterised by catabolic and inflammatory
processes that contribute largely to tissue degradation and chronic back pain. The disc cells …

[HTML][HTML] Peptidoglycan switches off the TLR2-mediated sperm recognition and triggers sperm localization in the bovine endometrium

IF Elesh, MA Marey, MA Zinnah, I Akthar… - Frontiers in …, 2021 - frontiersin.org
In mammals, the uterine mucosal immune system simultaneously recognizes and reacts to
most bacteria as well as allogenic sperm mainly through the Toll-like receptors (TLR) 2/4 …

Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders

S Miller, MJ Blanco - RSC Medicinal Chemistry, 2021 - pubs.rsc.org
Chronically activated microglia and the resulting cascade of neuroinflammatory mechanisms
have been postulated to play a critical role in neurodegenerative disorders. Microglia are the …

Role of atypical chemokines and chemokine receptors pathways in the pathogenesis of COPD

F Nucera, F Lo Bello, SS Shen… - Current medicinal …, 2021 - ingentaconnect.com
Chronic obstructive pulmonary disease (COPD) represents a heightened inflammatory
response in the lung generally resulting from tobacco smoking-induced recruitment and …