Depression is common in older individuals and is associated with high disability and
mortality. A major problem is treatment resistance:> 50% of older patients do not respond to …

Importance Observational studies have reported associations between antihypertensive
medication and psychiatric disorders, although the reported direction of association appears …

Beyond blood pressure control, angiotensin receptor blockers reduce common injury
mechanisms, decreasing excessive inflammation and protecting endothelial and …

Abstract About 20–30% of patients with major depressive disorder (MDD) develop treatment-
resistant depression (TRD) and finding new effective treatments for TRD has been a …

Background: Although numerous cohort studies have reported an association between
antihypertensives use and depression, the exact effect of antihypertensives on depression …

Traumatic brain injury (TBI) results in complex pathological reactions, where the initial lesion
is followed by secondary inflammation and edema. Our laboratory and others have reported …

The major anti-hypertensive (AHT) drug classes have been associated with differential risks
of psychiatric disorders. However, existing data are limited largely to depression, and …

BackgroundRecent work suggests that antihypertensive medications may be useful as
repurposed treatments for mood disorders. Using large-scale linked healthcare data we …

Background Bipolar disorder (BD) is associated with excess and premature cardiovascular
mortality. Elevated blood pressure (BP) is a leading contributor to cardiovascular risk …

Objective It is well known that post-stroke depression might be a negative factor for stroke
recovery, however there is limited evidence to establish the link between pre-stroke …