Adrenocortical carcinoma: current state of the art, ongoing controversies, and future directions in diagnosis and treatment

OA Shariq, TJ McKenzie - Therapeutic Advances in Chronic …, 2021 - journals.sagepub.com
Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with an annual incidence
of~ 1 case per million population. Differentiating between ACC and benign adrenocortical …

Current status and future targeted therapy in adrenocortical cancer

G Alyateem, N Nilubol - Frontiers in Endocrinology, 2021 - frontiersin.org
Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis. The current
treatment standards include complete surgical resection for localized resectable disease …

Surgical management of adrenocortical carcinoma: current highlights

G Cavallaro, M Tarallo, A Chiappini, D Crocetti… - Biomedicines, 2021 - mdpi.com
Introduction: Adrenocortical carcinoma (ACC) is a rare tumor, often discovered at an
advanced stage and associated with poor prognosis. Treatment is guided by staging …

Implications of conversion during attempted minimally invasive adrenalectomy for adrenocortical carcinoma

OM Delozier, ZE Stiles, BW Deschner, JA Drake… - Annals of surgical …, 2021 - Springer
Background Although advocated by some, minimally invasive adrenalectomy (MIA) for
adrenocortical carcinoma (ACC) is controversial. Moreover, the oncologic implications for …

Integrative computational immunogenomic profiling of cortisol‐secreting adrenocortical carcinoma

JJ Baechle, DN Hanna, KR Sekhar… - Journal of Cellular …, 2021 - Wiley Online Library
Adrenocortical carcinoma (ACC) is a rare but highly aggressive malignancy. Nearly half of
ACC tumours overproduce and secrete adrenal steroids. Excess cortisol secretion, in …

Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma

VB Brondani, AMF Lacombe, BMP Mariani… - International Journal of …, 2021 - mdpi.com
Adrenocortical carcinoma (ACC) is a rare malignancy that is associated with a dismal
prognosis. Pan-genomic studies have demonstrated the involvement of ATRX and ZNRF3 …

Cumulative GRAS score as a predictor of survival after resection for adrenocortical carcinoma: analysis from the US adrenocortical carcinoma database

JJ Baechle, P Marincola Smith, CC Solórzano… - Annals of surgical …, 2021 - Springer
Background Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy, and
many prognostic factors that influence survival remain undefined. Individually, the GRAS …

Molecular genomic profiling of adrenocortical cancers in clinical practice

S Darabi, DR Braxton, BL Eisenberg, MJ Demeure - Surgery, 2021 - Elsevier
Abstract Background At presentation, 21% to 49% of patients with adrenocortical cancer
have metastases. Standard chemotherapy has a 23% response rate. We assessed whether …

Association between preoperative serum albumin and prognosis in patients with adrenocortical carcinoma after primary resection: a retrospective study

F Zhang, Z Liu, J Liang, S Liu, K Wu, F Zhang, C Zhou… - BMC cancer, 2021 - Springer
Background Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with a
poor prognosis. Given the limited treatment options, prognostic assessment of ACC is …

Construction of a robust prognostic model for adult adrenocortical carcinoma: Results from bioinformatics and real‐world data

X Tian, WH Xu, A Anwaier, HK Wang… - Journal of cellular …, 2021 - Wiley Online Library
This study aims to construct a robust prognostic model for adult adrenocortical carcinoma
(ACC) by large‐scale multiomics analysis and real‐world data. The RPPA data, gene …