[HTML][HTML] Association between statin use and clinical course, microbiologic characteristics, and long-term outcome of early Lyme borreliosis. A post hoc analysis of …

D Stupica, FF Bajrović, R Blagus, T Cerar Kišek… - Plos one, 2021 - journals.plos.org
Background Statins were shown to inhibit borrelial growth in vitro and promote clearance of
spirochetes in a murine model of Lyme borreliosis (LB). We investigated the impact of statin …

[HTML][HTML] Borrelia peptidoglycan interacting Protein (BpiP) contributes to the fitness of Borrelia burgdorferi against host-derived factors and influences virulence in …

Y Chen, SM Vargas, TC Smith, SLR Karna… - PLoS …, 2021 - journals.plos.org
The Peptidoglycan (PG) cell wall of the Lyme disease (LD) spirochete, Borrelia burgdorferi
(Bb), contributes to structural and morphological integrity of Bb; is a persistent antigen in LD …

Statins as host-directed therapy for tuberculosis

NK Dutta, PC Karakousis - Advances in host-directed therapies against …, 2021 - Springer
Statins are a class of drugs that inhibit HMG-CoA reductase, the rate-limiting step in
cholesterol biosynthesis, and are commonly used for primary and secondary prevention of …

Borrelia Sulfate Transport Anti-sigma Antagonist Domain-Containing Protein (BSAP) Impacts Host-Dependent Adaptation of Borrelia burgdorferi

BE Moy - 2021 - search.proquest.com
Borrelia burgdorferi, the agent of Lyme disease, is transmitted to humans and other
mammalian hosts via the bite of infected Ixodes scapularis ticks. B. burgdorferi exhibits …