Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Background: Stroke has become a major problem around the world, which is one of the
main causes of long-term disability. Therefore, it is important to seek a biomarker to predict …

Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme for
polyunsaturated fatty acids (PUFAs) metabolism that dictates ferroptosis sensitivity. The role …

Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic
stroke. However, the current clinical treatments are remained on single pathological …

Purpose Cerebral ischemia induces a profound neuro-inflammatory response, but the
underlying molecular mechanisms are poorly understood. Inflammasomes (NLRP1, NLRP3 …

In recent years, preclinical studies have illustrated the potential role of intestinal bacterial
composition in the risk of stroke and post-stroke infections. The results of these studies …

Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG), cell-
surface-associated biopolymer and is the key component of tissue extracellular matrix …

During the last decade, experimental and clinical studies have demonstrated that isolated
acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and …

Ischemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to
the brain. Ischemia would initiate the cascade reaction consisted of multiple biochemical …

Stroke is one of most common causes of death and disability. Most of neuroprotective agents
fail to rescue neurons from cerebral ischemic insults, mainly because of targeting …