Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

Acetaminophen (ACT) is an effective and widely available analgesic and antipyretic used in
medical practice. It can get into water from veterinary use, medical waste and …

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at
therapeutic doses but can cause severe liver injury and even liver failure after overdoses …

Objective Non-alcoholic fatty liver disease (NAFLD) is an aberrant lipid metabolism disease.
Hypoxia inducible factor-1 (HIF-1α) is a transcription factor which plays an important part in …

Acetaminophen (APAP) hepatotoxicity is the most frequent cause of acute liver failure in the
US. The mechanisms of APAP-induced liver injury have been under extensive investigations …

Acetaminophen (APAP)-induced liver injury is associated with activation of coagulation and
fibrinolysis. In mice, both tissue factor–dependent thrombin generation and plasmin activity …

Drug induced liver injury (DILI) is a major cause of acute liver failure (ALF) and one of the
leading indications for liver transplantation in Western societies. Given the wide use of both …

Overdose acetaminophen (APAP) can result in severe liver injury, which is responsible for
nearly half of drug-induced liver injury in western countries. Previous studies have found that …

The flavonoid quercitrin has a strong antioxidant property. It is also reported to have a
protective effect on the liver. However, the mechanism by which it exerts a protective effect …

Acetaminophen (APAP), one of the most widely used antipyretic and analgesic drugs,
principally contributes to drug-induced liver injury when taken at a high dose. APAP-induced …